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| 001 | 124428 | ||
| 005 | 20240228145514.0 | ||
| 024 | 7 | _ | |a 10.1002/mrm.26370 |2 doi |
| 024 | 7 | _ | |a pmid:27521026 |2 pmid |
| 024 | 7 | _ | |a 0740-3194 |2 ISSN |
| 024 | 7 | _ | |a 1522-2594 |2 ISSN |
| 024 | 7 | _ | |a altmetric:10535264 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-01305 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Schuenke, Patrick |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2017 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1661166962_31348 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Chemical exchange sensitive spin-lock and related techniques allow to observe the uptake of administered D-glucose in vivo. The exchange-weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequency (RF) field at ultrahigh field whole-body scanners lead to artifacts in conventional spin-lock experiments. Thus, our aim was the development of an adiabatically prepared T1ρ -based imaging sequence applicable to studies of glucose metabolism in tumor patients at ultrahigh field strengths.An adiabatically prepared on-resonant spin-lock approach was realized at a 7 Tesla whole-body scanner and compared with conventional spin-lock. The insensitivity to RF field inhomogeneities as well as the chemical exchange sensitivity of the approach was investigated in simulations, model solutions and in the human brain.The suggested spin-lock approach was shown to be feasible for in vivo application at ultrahigh field whole-body scanners and showed substantially improved image quality compared with conventional spin-lock. The sensitivity of the presented method to glucose was verified in model solutions and a glucose contrast was observed in a glioblastoma patient after intravenous administration of glucose solution.An adiabatically prepared spin-lock preparation was presented that enables a homogeneous and chemical exchange sensitive T1ρ -based imaging at ultra-high field whole-body scanners, e.g., for T1ρ -based dynamic glucose enhanced MRI. Magn Reson Med 78:215-225, 2017. © 2016 International Society for Magnetic Resonance in Medicine. |
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| 700 | 1 | _ | |a Koehler, Christina |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Korzowski, Andreas |0 P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e |b 2 |u dkfz |
| 700 | 1 | _ | |a Windschuh, Johannes |0 P:(DE-He78)98b696ed60c17f4ddd0da9fdc20a2492 |b 3 |u dkfz |
| 700 | 1 | _ | |a Bachert, Peter |0 P:(DE-He78)29b2f01310f7022916255ddba2750f9b |b 4 |u dkfz |
| 700 | 1 | _ | |a Ladd, Mark |0 P:(DE-He78)022611a2317e4de40fd912e0a72293a8 |b 5 |u dkfz |
| 700 | 1 | _ | |a Mundiyanapurath, Sibu |b 6 |
| 700 | 1 | _ | |a Paech, Daniel |0 P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc |b 7 |u dkfz |
| 700 | 1 | _ | |a Bickelhaupt, Sebastian |0 P:(DE-He78)d2d971750bce6217eb90fff9b01e61f9 |b 8 |u dkfz |
| 700 | 1 | _ | |a Bonekamp, David |0 P:(DE-He78)ea098e4d78abeb63afaf8c25ec6d6d93 |b 9 |u dkfz |
| 700 | 1 | _ | |a Schlemmer, Heinz-Peter |0 P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec |b 10 |u dkfz |
| 700 | 1 | _ | |a Radbruch, Alexander |0 P:(DE-He78)77588f5b9413339755a66e739d316c7d |b 11 |u dkfz |
| 700 | 1 | _ | |a Zaiss, Moritz |0 P:(DE-He78)db923d831c5fe9b5e8fab7794dd45c44 |b 12 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/mrm.26370 |g Vol. 78, no. 1, p. 215 - 225 |0 PERI:(DE-600)1493786-4 |n 1 |p 215 - 225 |t Magnetic resonance in medicine |v 78 |y 2017 |x 0740-3194 |
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