%0 Journal Article
%A Margolin-Miller, Yulia
%A Yanichkin, Natalia
%A Shichrur, Keren
%A Toledano, Helen
%A Ohali, Anat
%A Tzaridis, Theophilos
%A Michowitz, Shalom
%A Fichman-Horn, Suzana
%A Feinmesser, Meora
%A Pfister, Stefan
%A Witt, Hendrik
%A Tabori, Uri
%A Bouffet, Eric
%A Ramaswamy, Vijay
%A Hawkins, Cynthia
%A Taylor, Michael D
%A Yaniv, Isaac
%A Avigad, Smadar
%T Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma.
%J Genes, chromosomes & cancer
%V 56
%N 8
%@ 1045-2257
%C New York, NY
%I Wiley-Liss
%M DKFZ-2017-01311
%P 639 - 650
%D 2017
%X Ependymoma is a malignant pediatric brain tumor, often incurable under the current treatment regimen. We aimed to evaluate the expression of microRNAs (miRs) in pediatric ependymoma tumors in an attempt to identify prognostic molecular markers which would lead to potential therapeutic targets. Following miR-array expression analysis, we focused on 9 miRs that correlated with relapse which were further validated by quantitative real-time PCR (qRT-PCR) in a cohort of 67 patients. Western blotting and immunohistochemistry were used to measure target protein expression in 20 and 34 tumor samples, respectively. High expression of miR-124-3p significantly correlated with the lower progression-free survival (PFS) of 16
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28437838
%R 10.1002/gcc.22467
%U https://inrepo02.dkfz.de/record/124434