TY  - JOUR
AU  - Margolin-Miller, Yulia
AU  - Yanichkin, Natalia
AU  - Shichrur, Keren
AU  - Toledano, Helen
AU  - Ohali, Anat
AU  - Tzaridis, Theophilos
AU  - Michowitz, Shalom
AU  - Fichman-Horn, Suzana
AU  - Feinmesser, Meora
AU  - Pfister, Stefan
AU  - Witt, Hendrik
AU  - Tabori, Uri
AU  - Bouffet, Eric
AU  - Ramaswamy, Vijay
AU  - Hawkins, Cynthia
AU  - Taylor, Michael D
AU  - Yaniv, Isaac
AU  - Avigad, Smadar
TI  - Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma.
JO  - Genes, chromosomes & cancer
VL  - 56
IS  - 8
SN  - 1045-2257
CY  - New York, NY
PB  - Wiley-Liss
M1  - DKFZ-2017-01311
SP  - 639 - 650
PY  - 2017
AB  - Ependymoma is a malignant pediatric brain tumor, often incurable under the current treatment regimen. We aimed to evaluate the expression of microRNAs (miRs) in pediatric ependymoma tumors in an attempt to identify prognostic molecular markers which would lead to potential therapeutic targets. Following miR-array expression analysis, we focused on 9 miRs that correlated with relapse which were further validated by quantitative real-time PCR (qRT-PCR) in a cohort of 67 patients. Western blotting and immunohistochemistry were used to measure target protein expression in 20 and 34 tumor samples, respectively. High expression of miR-124-3p significantly correlated with the lower progression-free survival (PFS) of 16
LB  - PUB:(DE-HGF)16
C6  - pmid:28437838
DO  - DOI:10.1002/gcc.22467
UR  - https://inrepo02.dkfz.de/record/124434
ER  -