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@ARTICLE{Straub:124445,
      author       = {S. Straub$^*$ and T. Schneider$^*$ and J. Emmerich$^*$ and
                      M. Freitag$^*$ and C. Ziener$^*$ and H.-P. Schlemmer$^*$ and
                      M. Ladd$^*$ and F. Laun$^*$},
      title        = {{S}uitable reference tissues for quantitative
                      susceptibility mapping of the brain.},
      journal      = {Magnetic resonance in medicine},
      volume       = {78},
      number       = {1},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-01322},
      pages        = {204 - 214},
      year         = {2017},
      abstract     = {Since quantitative susceptibility mapping (QSM) quantifies
                      magnetic susceptibility relative to a reference value, a
                      suitable reference tissue has to be available to compare
                      different subjects and stages of disease.To find such a
                      suitable reference tissue for QSM of the brain, melanoma
                      patients with and without brain metastases were measured.
                      Twelve reference regions were chosen and assessed for
                      stability of susceptibility values with respect to multiple
                      intra-individual and inter-individual measurements, age, and
                      stage of disease.Cerebrospinal fluid (CSF), the internal
                      capsule and one region in the splenium of the corpus
                      callosum are the regions with the smallest standard
                      deviations of the mean susceptibility value. The mean
                      susceptibility is 0.010 ± 0.014 ppm for CSF in the
                      atrium of the lateral ventricles (csfpost ), -0.060 ±
                      0.019 ppm for the posterior limb of the internal capsule
                      (ci2), and -0.008 ± 0.019 ppm for the splenium of the
                      corpus callosum. csfpost and ci2 show nearly no dependence
                      on age or stage of disease, whereas some other regions,
                      e.g., the red nucleus, show moderate dependence on age or
                      disease.The internal capsule and CSF appear to be the most
                      suitable reference regions for QSM of the brain in the
                      melanoma patients studied. Both showed virtually no
                      dependence on age or disease and small variations among
                      patients. Magn Reson Med 78:204-214, 2017. © 2016
                      International Society for Magnetic Resonance in Medicine.},
      cin          = {E020 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27529579},
      doi          = {10.1002/mrm.26369},
      url          = {https://inrepo02.dkfz.de/record/124445},
}