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@ARTICLE{Jou:124459,
      author       = {A. Jou$^*$ and J. Hess$^*$},
      title        = {{E}pidemiology and {M}olecular {B}iology of {H}ead and
                      {N}eck {C}ancer.},
      journal      = {Oncology research and treatment},
      volume       = {40},
      number       = {6},
      issn         = {2296-5262},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DKFZ-2017-01336},
      pages        = {328 - 332},
      year         = {2017},
      abstract     = {Head and neck cancer is a common and aggressive malignancy
                      with a high morbidity and mortality profile. Although the
                      large majority of cases resemble head and neck squamous cell
                      carcinoma (HNSCC), the current classification based on
                      anatomic site and tumor stage fails to capture the high
                      level of biologic heterogeneity, and appropriate clinical
                      management remains a major challenge. Hence, a better
                      understanding of the molecular biology of HNSCC is urgently
                      needed to support biomarker development and personalized
                      care for patients. This review focuses on recent findings
                      based on integrative genomics analysis and multi-scale
                      modeling approaches and how they are beginning to provide
                      more sophisticated clues as to the biological and clinical
                      diversity of HNSCC.},
      subtyp        = {Review Article},
      cin          = {G405},
      ddc          = {610},
      cid          = {I:(DE-He78)G405-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28531899},
      doi          = {10.1159/000477127},
      url          = {https://inrepo02.dkfz.de/record/124459},
}