000125202 001__ 125202
000125202 005__ 20240228145517.0
000125202 0247_ $$2doi$$a10.1084/jem.20162017
000125202 0247_ $$2pmid$$apmid:28572216
000125202 0247_ $$2pmc$$apmc:PMC5502434
000125202 0247_ $$2ISSN$$a0022-1007
000125202 0247_ $$2ISSN$$a1540-9538
000125202 0247_ $$2altmetric$$aaltmetric:20869968
000125202 037__ $$aDKFZ-2017-01357
000125202 041__ $$aeng
000125202 082__ $$a610
000125202 1001_ $$0P:(DE-He78)30359063e6dfdc26aeb476fcd7cf696f$$aGiessler, Klara$$b0$$eFirst author$$udkfz
000125202 245__ $$aGenetic subclone architecture of tumor clone-initiating cells in colorectal cancer.
000125202 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2017
000125202 3367_ $$2DRIVER$$aarticle
000125202 3367_ $$2DataCite$$aOutput Types/Journal article
000125202 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1533719084_21515
000125202 3367_ $$2BibTeX$$aARTICLE
000125202 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000125202 3367_ $$00$$2EndNote$$aJournal Article
000125202 520__ $$aA hierarchically organized cell compartment drives colorectal cancer (CRC) progression. Genetic barcoding allows monitoring of the clonal output of tumorigenic cells without prospective isolation. In this study, we asked whether tumor clone-initiating cells (TcICs) were genetically heterogeneous and whether differences in self-renewal and activation reflected differential kinetics among individual subclones or functional hierarchies within subclones. Monitoring genomic subclone kinetics in three patient tumors and corresponding serial xenografts and spheroids by high-coverage whole-genome sequencing, clustering of genetic aberrations, subclone combinatorics, and mutational signature analysis revealed at least two to four genetic subclones per sample. Long-term growth in serial xenografts and spheroids was driven by multiple genomic subclones with profoundly differing growth dynamics and hence different quantitative contributions over time. Strikingly, genetic barcoding demonstrated stable functional heterogeneity of CRC TcICs during serial xenografting despite near-complete changes in genomic subclone contribution. This demonstrates that functional heterogeneity is, at least frequently, present within genomic subclones and independent of mutational subclone differences.
000125202 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000125202 588__ $$aDataset connected to CrossRef, PubMed,
000125202 7001_ $$00000-0002-1859-2281$$aKleinheinz, Kortine$$b1$$eFirst author
000125202 7001_ $$00000-0002-6041-7049$$aHuebschmann, Daniel$$b2
000125202 7001_ $$0P:(DE-HGF)0$$aBalasubramanian, Gnana Prakash$$b3
000125202 7001_ $$0P:(DE-He78)fd92a33f8a02f962db52bf8daa1b1dbf$$aDubash, Taronish Dorab$$b4$$udkfz
000125202 7001_ $$00000-0003-1324-7638$$aDieter, Sebastian M$$b5
000125202 7001_ $$0P:(DE-He78)be98d27bcd782f4e5961b646107dc14b$$aSiegl, Christine$$b6
000125202 7001_ $$0P:(DE-He78)13dc15153ce40f775007112548f34d79$$aHerbst, Friederike$$b7
000125202 7001_ $$0P:(DE-He78)4f46d49c3232f5f84d315c1fcb36943e$$aWeber, Sarah$$b8
000125202 7001_ $$00000-0001-8529-9678$$aHoffmann, Christopher M$$b9
000125202 7001_ $$0P:(DE-He78)c2585457f370249465a2080111937cf5$$aFronza, Raffaele$$b10
000125202 7001_ $$00000-0003-0764-5832$$aBuchhalter, Ivo$$b11
000125202 7001_ $$0P:(DE-He78)4a8b73f9f05542860120bb0e19527fd2$$aParamasivam, Nagarajan$$b12
000125202 7001_ $$0P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0$$aEils, Roland$$b13
000125202 7001_ $$0P:(DE-He78)b91bec47a4148ba68a58ab292d5860f2$$aSchmidt, Manfred$$b14
000125202 7001_ $$0P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de$$avon Kalle, Christof$$b15
000125202 7001_ $$aSchneider, Martin$$b16
000125202 7001_ $$aUlrich, Alexis$$b17
000125202 7001_ $$0P:(DE-He78)2c1a21d1cf5fdc9e297512c9d1354250$$aScholl, Claudia$$b18
000125202 7001_ $$0P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aFröhling, Stefan$$b19
000125202 7001_ $$0P:(DE-HGF)0$$aWeichert, Wilko$$b20
000125202 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b21
000125202 7001_ $$00000-0002-5896-4086$$aSchlesner, Matthias$$b22
000125202 7001_ $$00000-0002-1749-3791$$aBall, Claudia R$$b23
000125202 7001_ $$00000-0003-4104-1135$$aGlimm, Hanno$$b24$$eLast author
000125202 773__ $$0PERI:(DE-600)1477240-1$$a10.1084/jem.20162017$$gVol. 214, no. 7, p. 2073 - 2088$$n7$$p2073 - 2088$$tJournal of experimental medicine$$v214$$x1540-9538$$y2017
000125202 909CO $$ooai:inrepo02.dkfz.de:125202$$pVDB
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)30359063e6dfdc26aeb476fcd7cf696f$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-1859-2281$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-6041-7049$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fd92a33f8a02f962db52bf8daa1b1dbf$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0003-1324-7638$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)be98d27bcd782f4e5961b646107dc14b$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)13dc15153ce40f775007112548f34d79$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4f46d49c3232f5f84d315c1fcb36943e$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c2585457f370249465a2080111937cf5$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0003-0764-5832$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4a8b73f9f05542860120bb0e19527fd2$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b91bec47a4148ba68a58ab292d5860f2$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2c1a21d1cf5fdc9e297512c9d1354250$$aDeutsches Krebsforschungszentrum$$b18$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aDeutsches Krebsforschungszentrum$$b19$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fc949170377b58098e46141d95c72661$$aDeutsches Krebsforschungszentrum$$b21$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-5896-4086$$aDeutsches Krebsforschungszentrum$$b22$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-1749-3791$$aDeutsches Krebsforschungszentrum$$b23$$kDKFZ
000125202 9101_ $$0I:(DE-588b)2036810-0$$60000-0003-4104-1135$$aDeutsches Krebsforschungszentrum$$b24$$kDKFZ
000125202 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000125202 9141_ $$y2017
000125202 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000125202 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000125202 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ EXP MED : 2015
000125202 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000125202 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000125202 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000125202 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000125202 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000125202 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000125202 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000125202 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bJ EXP MED : 2015
000125202 9201_ $$0I:(DE-He78)B080-20160331$$kB080$$lTheoretische Bioinformatik$$x0
000125202 9201_ $$0I:(DE-He78)G100-20160331$$kG100$$lTranslationale Onkologie$$x1
000125202 9201_ $$0I:(DE-He78)G200-20160331$$kG200$$lAngewandte Bioinformatik$$x2
000125202 9201_ $$0I:(DE-He78)G102-20160331$$kG102$$lAngewandte Funktionelle Genomik$$x3
000125202 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x4
000125202 9201_ $$0I:(DE-He78)L701-20160331$$kL701$$lDKTK München$$x5
000125202 980__ $$ajournal
000125202 980__ $$aVDB
000125202 980__ $$aI:(DE-He78)B080-20160331
000125202 980__ $$aI:(DE-He78)G100-20160331
000125202 980__ $$aI:(DE-He78)G200-20160331
000125202 980__ $$aI:(DE-He78)G102-20160331
000125202 980__ $$aI:(DE-He78)L101-20160331
000125202 980__ $$aI:(DE-He78)L701-20160331
000125202 980__ $$aUNRESTRICTED