%0 Journal Article
%A Mons, Ute
%A Müezzinler, Aysel
%A Schöttker, Ben
%A Dieffenbach, Aida Karina
%A Butterbach, Katja
%A Schick, Matthias
%A Peasey, Anne
%A De Vivo, Immaculata
%A Trichopoulou, Antonia
%A Boffetta, Paolo
%A Brenner, Hermann
%T Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies.
%J American journal of epidemiology
%V 185
%N 12
%@ 1476-6256
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2017-01373
%P 1317 - 1326
%D 2017
%X We studied the associations of leukocyte telomere length (LTL) with all-cause, cardiovascular disease, and cancer mortality in 12,199 adults participating in 2 population-based prospective cohort studies from Europe (ESTHER) and the United States (Nurses' Health Study). Blood samples were collected in 1989-1990 (Nurses' Health Study) and 2000-2002 (ESTHER). LTL was measured by quantitative polymerase chain reaction. We calculated z scores for LTL to standardize LTL measurements across the cohorts. Cox proportional hazards regression models were used to calculate relative mortality according to continuous levels and quintiles of LTL z scores. The hazard ratios obtained from each cohort were subsequently pooled by meta-analysis. Overall, 2,882 deaths were recorded during follow-up (Nurses' Health Study, 1989-2010; ESTHER, 2000-2015). LTL was inversely associated with age in both cohorts. After adjustment for age, a significant inverse trend of LTL with all-cause mortality was observed in both cohorts. In random-effects meta-analysis, age-adjusted hazard ratios for the shortest LTL quintile compared with the longest were 1.23 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28459963
%R 10.1093/aje/kww210
%U https://inrepo02.dkfz.de/record/125218