TY  - JOUR
AU  - Mons, Ute
AU  - Müezzinler, Aysel
AU  - Schöttker, Ben
AU  - Dieffenbach, Aida Karina
AU  - Butterbach, Katja
AU  - Schick, Matthias
AU  - Peasey, Anne
AU  - De Vivo, Immaculata
AU  - Trichopoulou, Antonia
AU  - Boffetta, Paolo
AU  - Brenner, Hermann
TI  - Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies.
JO  - American journal of epidemiology
VL  - 185
IS  - 12
SN  - 1476-6256
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2017-01373
SP  - 1317 - 1326
PY  - 2017
AB  - We studied the associations of leukocyte telomere length (LTL) with all-cause, cardiovascular disease, and cancer mortality in 12,199 adults participating in 2 population-based prospective cohort studies from Europe (ESTHER) and the United States (Nurses' Health Study). Blood samples were collected in 1989-1990 (Nurses' Health Study) and 2000-2002 (ESTHER). LTL was measured by quantitative polymerase chain reaction. We calculated z scores for LTL to standardize LTL measurements across the cohorts. Cox proportional hazards regression models were used to calculate relative mortality according to continuous levels and quintiles of LTL z scores. The hazard ratios obtained from each cohort were subsequently pooled by meta-analysis. Overall, 2,882 deaths were recorded during follow-up (Nurses' Health Study, 1989-2010; ESTHER, 2000-2015). LTL was inversely associated with age in both cohorts. After adjustment for age, a significant inverse trend of LTL with all-cause mortality was observed in both cohorts. In random-effects meta-analysis, age-adjusted hazard ratios for the shortest LTL quintile compared with the longest were 1.23 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:28459963
DO  - DOI:10.1093/aje/kww210
UR  - https://inrepo02.dkfz.de/record/125218
ER  -