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@ARTICLE{Mons:125218,
      author       = {U. Mons$^*$ and A. Müezzinler$^*$ and B. Schöttker$^*$
                      and A. K. Dieffenbach$^*$ and K. Butterbach$^*$ and M.
                      Schick$^*$ and A. Peasey and I. De Vivo and A. Trichopoulou
                      and P. Boffetta and H. Brenner$^*$},
      title        = {{L}eukocyte {T}elomere {L}ength and {A}ll-{C}ause,
                      {C}ardiovascular {D}isease, and {C}ancer {M}ortality:
                      {R}esults {F}rom {I}ndividual-{P}articipant-{D}ata
                      {M}eta-{A}nalysis of 2 {L}arge {P}rospective {C}ohort
                      {S}tudies.},
      journal      = {American journal of epidemiology},
      volume       = {185},
      number       = {12},
      issn         = {1476-6256},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2017-01373},
      pages        = {1317 - 1326},
      year         = {2017},
      abstract     = {We studied the associations of leukocyte telomere length
                      (LTL) with all-cause, cardiovascular disease, and cancer
                      mortality in 12,199 adults participating in 2
                      population-based prospective cohort studies from Europe
                      (ESTHER) and the United States (Nurses' Health Study). Blood
                      samples were collected in 1989-1990 (Nurses' Health Study)
                      and 2000-2002 (ESTHER). LTL was measured by quantitative
                      polymerase chain reaction. We calculated z scores for LTL to
                      standardize LTL measurements across the cohorts. Cox
                      proportional hazards regression models were used to
                      calculate relative mortality according to continuous levels
                      and quintiles of LTL z scores. The hazard ratios obtained
                      from each cohort were subsequently pooled by meta-analysis.
                      Overall, 2,882 deaths were recorded during follow-up
                      (Nurses' Health Study, 1989-2010; ESTHER, 2000-2015). LTL
                      was inversely associated with age in both cohorts. After
                      adjustment for age, a significant inverse trend of LTL with
                      all-cause mortality was observed in both cohorts. In
                      random-effects meta-analysis, age-adjusted hazard ratios for
                      the shortest LTL quintile compared with the longest were
                      1.23 $(95\%$ confidence interval (CI): 1.04, 1.46) for
                      all-cause mortality, 1.29 $(95\%$ CI: 0.83, 2.00) for
                      cardiovascular mortality, and 1.10 $(95\%$ CI: 0.88, 1.37)
                      for cancer mortality. In this study population with an age
                      range of 43-75 years, we corroborated previous evidence
                      suggesting that LTL predicts all-cause mortality beyond its
                      association with age.},
      subtyp        = {Review Article},
      cin          = {M050 / C070 / L101 / W110},
      ddc          = {610},
      cid          = {I:(DE-He78)M050-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)W110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28459963},
      doi          = {10.1093/aje/kww210},
      url          = {https://inrepo02.dkfz.de/record/125218},
}