%0 Journal Article
%A Pearson, Andrew D J
%A Pfister, Stefan
%A Baruchel, Andre
%A Bourquin, Jean-Pierre
%A Casanova, Michela
%A Chesler, Louis
%A Doz, François
%A Eggert, Angelika
%A Geoerger, Birgit
%A Jones, David
%A Kearns, Pamela R
%A Molenaar, Jan J
%A Morland, Bruce
%A Schleiermacher, Gudrun
%A Schulte, Johannes
%A Vormoor, Josef
%A Marshall, Lynley V
%A Zwaan, C Michel
%A Vassal, Gilles
%T From class waivers to precision medicine in paediatric oncology.
%J The lancet  / Oncology
%V 18
%N 7
%@ 1470-2045
%C London
%I The Lancet Publ. Group
%M DKFZ-2017-01374
%P e394 - e404
%D 2017
%X New drugs are crucially needed for children with cancer. The European Paediatric Regulation facilitates paediatric class waivers for drugs developed for diseases only occurring in adults. In this Review, we retrospectively searched oncology drugs that were class waivered between June, 2012, and June, 2015. 147 oncology class waivers were confirmed for 89 drugs. Mechanisms of action were then assessed as potential paediatric therapeutic targets by both a literature search and an expert review. 48 (54
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28677575
%R 10.1016/S1470-2045(17)30442-4
%U https://inrepo02.dkfz.de/record/125219