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000125276 1001_ $$0P:(DE-He78)79264e5eb093c3b6fe517e4ca29da19b$$aBrunk, Fabian$$b0$$eFirst author$$udkfz
000125276 245__ $$aDissecting and modeling the emergent murine TEC compartment during ontogeny.
000125276 260__ $$aWeinheim$$bWiley-VCH$$c2017
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000125276 520__ $$aThe origin of the thymic epithelium, i.e. the cortical (cTEC) and medullary (mTEC) epithelial cells, from bipotent stem cells through TEC progenitors and lineage-specific progeny still remains poorly understood. We sought to obtain an unbiased view of the incipient emergence of TEC subsets by following embryonic TEC development based on co-expression of EpCAM, CD80 and MHC class II (MHCII) on non-hematopoietic (CD45(-) ) thymic stromal cells in wild-type BL6 mice. Using a combination of ex vivo analysis, Re-aggregate Thymic Organ Culture (RTOC) reconstitution assays and mathematical modeling, we traced emergent lineage commitment in murine embryonic TECs. Both experimental and mathematical datasets supported the following developmental sequence: MHCII(-) CD80(-) → MHCII(lo) CD80(-) → MHCII(hi) CD80(-) → MHCII(hi) CD80(hi) TECs, whereby MHCII(hi) CD80(-) and MHCII(hi) CD80(hi) TECs bear features of cTECs and mTECs respectively. These emergent MHCII(hi) CD80(-) cTECs directly generate mature MHCII(hi) CD80(hi) mTECs in vivo and in vitro, thus supporting the asynchronous model of TEC lineage commitment.
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000125276 7001_ $$0P:(DE-He78)a4cd801173d81a4409262f88a8ecdf55$$aMichel, Chloé$$b1$$udkfz
000125276 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b2$$udkfz
000125276 7001_ $$aSlynko, Alla$$b3
000125276 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b4$$udkfz
000125276 7001_ $$00000-0002-1327-0208$$aKyewski, Bruno$$b5
000125276 7001_ $$0P:(DE-He78)d2f9dbffa7b9a979f9bc4d81e769497e$$aPinto, Sheena$$b6$$eLast author$$udkfz
000125276 773__ $$0PERI:(DE-600)1491907-2$$a10.1002/eji.201747006$$gVol. 47, no. 7, p. 1153 - 1159$$n7$$p1153 - 1159$$tEuropean journal of immunology$$v47$$x0014-2980$$y2017
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