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@ARTICLE{Brunk:125276,
      author       = {F. Brunk$^*$ and C. Michel$^*$ and T. Holland-Letz$^*$ and
                      A. Slynko and A. Kopp-Schneider$^*$ and B. Kyewski$^*$ and
                      S. Pinto$^*$},
      title        = {{D}issecting and modeling the emergent murine {TEC}
                      compartment during ontogeny.},
      journal      = {European journal of immunology},
      volume       = {47},
      number       = {7},
      issn         = {0014-2980},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {DKFZ-2017-01415},
      pages        = {1153 - 1159},
      year         = {2017},
      abstract     = {The origin of the thymic epithelium, i.e. the cortical
                      (cTEC) and medullary (mTEC) epithelial cells, from bipotent
                      stem cells through TEC progenitors and lineage-specific
                      progeny still remains poorly understood. We sought to obtain
                      an unbiased view of the incipient emergence of TEC subsets
                      by following embryonic TEC development based on
                      co-expression of EpCAM, CD80 and MHC class II (MHCII) on
                      non-hematopoietic (CD45(-) ) thymic stromal cells in
                      wild-type BL6 mice. Using a combination of ex vivo analysis,
                      Re-aggregate Thymic Organ Culture (RTOC) reconstitution
                      assays and mathematical modeling, we traced emergent lineage
                      commitment in murine embryonic TECs. Both experimental and
                      mathematical datasets supported the following developmental
                      sequence: MHCII(-) CD80(-) → MHCII(lo) CD80(-) →
                      MHCII(hi) CD80(-) → MHCII(hi) CD80(hi) TECs, whereby
                      MHCII(hi) CD80(-) and MHCII(hi) CD80(hi) TECs bear features
                      of cTECs and mTECs respectively. These emergent MHCII(hi)
                      CD80(-) cTECs directly generate mature MHCII(hi) CD80(hi)
                      mTECs in vivo and in vitro, thus supporting the asynchronous
                      model of TEC lineage commitment.},
      cin          = {D090 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)D090-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28439878},
      doi          = {10.1002/eji.201747006},
      url          = {https://inrepo02.dkfz.de/record/125276},
}