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| 001 | 125276 | ||
| 005 | 20240228145520.0 | ||
| 024 | 7 | _ | |a 10.1002/eji.201747006 |2 doi |
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| 100 | 1 | _ | |a Brunk, Fabian |0 P:(DE-He78)79264e5eb093c3b6fe517e4ca29da19b |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Dissecting and modeling the emergent murine TEC compartment during ontogeny. |
| 260 | _ | _ | |a Weinheim |c 2017 |b Wiley-VCH |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a The origin of the thymic epithelium, i.e. the cortical (cTEC) and medullary (mTEC) epithelial cells, from bipotent stem cells through TEC progenitors and lineage-specific progeny still remains poorly understood. We sought to obtain an unbiased view of the incipient emergence of TEC subsets by following embryonic TEC development based on co-expression of EpCAM, CD80 and MHC class II (MHCII) on non-hematopoietic (CD45(-) ) thymic stromal cells in wild-type BL6 mice. Using a combination of ex vivo analysis, Re-aggregate Thymic Organ Culture (RTOC) reconstitution assays and mathematical modeling, we traced emergent lineage commitment in murine embryonic TECs. Both experimental and mathematical datasets supported the following developmental sequence: MHCII(-) CD80(-) → MHCII(lo) CD80(-) → MHCII(hi) CD80(-) → MHCII(hi) CD80(hi) TECs, whereby MHCII(hi) CD80(-) and MHCII(hi) CD80(hi) TECs bear features of cTECs and mTECs respectively. These emergent MHCII(hi) CD80(-) cTECs directly generate mature MHCII(hi) CD80(hi) mTECs in vivo and in vitro, thus supporting the asynchronous model of TEC lineage commitment. |
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| 700 | 1 | _ | |a Michel, Chloé |0 P:(DE-He78)a4cd801173d81a4409262f88a8ecdf55 |b 1 |u dkfz |
| 700 | 1 | _ | |a Holland-Letz, Tim |0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |b 2 |u dkfz |
| 700 | 1 | _ | |a Slynko, Alla |b 3 |
| 700 | 1 | _ | |a Kopp-Schneider, Annette |0 P:(DE-He78)bb6a7a70f976eb8df1769944bf913596 |b 4 |u dkfz |
| 700 | 1 | _ | |a Kyewski, Bruno |0 0000-0002-1327-0208 |b 5 |
| 700 | 1 | _ | |a Pinto, Sheena |0 P:(DE-He78)d2f9dbffa7b9a979f9bc4d81e769497e |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/eji.201747006 |g Vol. 47, no. 7, p. 1153 - 1159 |0 PERI:(DE-600)1491907-2 |n 7 |p 1153 - 1159 |t European journal of immunology |v 47 |y 2017 |x 0014-2980 |
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