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000125283 1001_ $$00000-0003-4536-9306$$aHorak, Peter$$b0$$eFirst author
000125283 245__ $$aPrecision oncology based on omics data: The NCT Heidelberg experience.
000125283 260__ $$aBognor Regis$$bWiley-Liss$$c2017
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000125283 520__ $$aPrecision oncology implies the ability to predict which patients will likely respond to specific cancer therapies based on increasingly accurate, high-resolution molecular diagnostics as well as the functional and mechanistic understanding of individual tumors. While molecular stratification of patients can be achieved through different means, a promising approach is next-generation sequencing of tumor DNA and RNA, which can reveal genomic alterations that have immediate clinical implications. Furthermore, certain genetic alterations are shared across multiple histologic entities, raising the fundamental question of whether tumors should be treated by molecular profile and not tissue of origin. We here describe MASTER (Molecularly Aided Stratification for Tumor Eradication Research), a clinically applicable platform for prospective, biology-driven stratification of younger adults with advanced-stage cancer across all histologies and patients with rare tumors. We illustrate how a standardized workflow for selection and consenting of patients, sample processing, whole-exome/genome and RNA sequencing, bioinformatic analysis, rigorous validation of potentially actionable findings, and data evaluation by a dedicated molecular tumor board enables categorization of patients into different intervention baskets and formulation of evidence-based recommendations for clinical management. Critical next steps will be to increase the number of patients that can be offered comprehensive molecular analysis through collaborations and partnering, to explore ways in which additional technologies can aid in patient stratification and individualization of treatment, to stimulate clinically guided exploratory research projects, and to gradually move away from assessing the therapeutic activity of targeted interventions on a case-by-case basis toward controlled clinical trials of genomics-guided treatments.
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000125283 7001_ $$0P:(DE-HGF)0$$aKlink, Barbara$$b1
000125283 7001_ $$0P:(DE-He78)1464357f7ec5faf677a390a414e50c88$$aHeining, Christoph$$b2
000125283 7001_ $$0P:(DE-He78)5120a331b1c28045c8ca6a8b1c73c95f$$aGröschel, Stefan$$b3
000125283 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b4
000125283 7001_ $$0P:(DE-He78)a15aa7d740f286aad9d8139d515e866c$$aFröhlich, Martina Antonia$$b5
000125283 7001_ $$0P:(DE-He78)a8e85c1bd89741ab0c2a28032ba81359$$aUhrig, Sebastian$$b6
000125283 7001_ $$0P:(DE-HGF)0$$aHübschmann, Daniel$$b7
000125283 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b8
000125283 7001_ $$0P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0$$aEils, Roland$$b9
000125283 7001_ $$0P:(DE-He78)29306fd3ae9f1a9839ed888ebc5c8074$$aRichter, Daniela$$b10
000125283 7001_ $$0P:(DE-He78)83906db1355a576371363a4b9f107d3d$$aPfütze, Katrin$$b11
000125283 7001_ $$0P:(DE-He78)3f888debb126ff36634df058ccaaf2b4$$aGeörg, Christina$$b12
000125283 7001_ $$0P:(DE-He78)9437a8b804d8cc2481997716ec66fa2f$$aMeißburger, Bettina$$b13
000125283 7001_ $$0P:(DE-He78)1efb774993effe7a66a6ffc1b1cf9ccb$$aWolf, Stephan$$b14
000125283 7001_ $$0P:(DE-He78)a0494aed1057846ea6c9bc93cacbe8e2$$aSchulz, Angela$$b15
000125283 7001_ $$aPenzel, Roland$$b16
000125283 7001_ $$aHerpel, Esther$$b17
000125283 7001_ $$0P:(DE-He78)3b9d10db5dbbf9eb21d02f77d99c8ac9$$aKirchner, Martina$$b18$$udkfz
000125283 7001_ $$0P:(DE-He78)f2177f299ad93efd161811e331914297$$aLier, Amelie$$b19$$udkfz
000125283 7001_ $$aEndris, Volker$$b20
000125283 7001_ $$aSinger, Stephan$$b21
000125283 7001_ $$0P:(DE-HGF)0$$aSchirmacher, Peter$$b22
000125283 7001_ $$0P:(DE-HGF)0$$aWeichert, Wilko$$b23
000125283 7001_ $$0P:(DE-HGF)0$$aStenzinger, Albrecht$$b24
000125283 7001_ $$0P:(DE-He78)d8a0e60e5e095f3161ee0de3712409bc$$aSchlenk, Richard$$b25
000125283 7001_ $$0P:(DE-HGF)0$$aSchröck, Evelin$$b26
000125283 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b27
000125283 7001_ $$0P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de$$avon Kalle, Christof$$b28
000125283 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b29
000125283 7001_ $$00000-0001-7907-4595$$aFröhling, Stefan$$b30$$eLast author
000125283 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.30828$$gVol. 141, no. 5, p. 877 - 886$$n5$$p877 - 886$$tInternational journal of cancer$$v141$$x0020-7136$$y2017
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