%0 Journal Article
%A Teichert, Martin
%A Milde, Laura
%A Holm, Annegret
%A Stanicek, Laura
%A Gengenbacher, Nicolas
%A Savant, Soniya
%A Ruckdeschel, Tina
%A Hasanov, Zulfiyya
%A Srivastava, Kshitij
%A Hu, Junhao
%A Hertel, Stella
%A Bartol, Arne
%A Schlereth, Katharina
%A Augustin, Hellmut G
%T Pericyte-expressed Tie2 controls angiogenesis and vessel maturation.
%J Nature Communications
%V 8
%@ 2041-1723
%C London
%I Nature Publishing Group
%M DKFZ-2017-01436
%P 16106 -
%D 2017
%X The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoietin/Tie signalling affects angiogenesis. Here we show that human and murine pericytes express functional Tie2 receptor. Silencing of Tie2 in pericytes results in a pro-migratory phenotype. Pericyte Tie2 controls sprouting angiogenesis in in vitro sprouting and in vivo spheroid assays. Tie2 downstream signalling in pericytes involves Calpain, Akt and FOXO3A. Ng2-Cre-driven deletion of pericyte-expressed Tie2 in mice transiently delays postnatal retinal angiogenesis. Yet, Tie2 deletion in pericytes results in a pronounced pro-angiogenic effect leading to enhanced tumour growth. Together, the data expand and revise the current concepts on vascular Angiopoietin/Tie signalling and propose a bidirectional, reciprocal EC-pericyte model of Tie2 signalling.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28719590
%2 pmc:PMC5520106
%R 10.1038/ncomms16106
%U https://inrepo02.dkfz.de/record/125298