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000125298 1001_ $$0P:(DE-HGF)0$$aTeichert, Martin$$b0$$eFirst author
000125298 245__ $$aPericyte-expressed Tie2 controls angiogenesis and vessel maturation.
000125298 260__ $$aLondon$$bNature Publishing Group$$c2017
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000125298 520__ $$aThe Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoietin/Tie signalling affects angiogenesis. Here we show that human and murine pericytes express functional Tie2 receptor. Silencing of Tie2 in pericytes results in a pro-migratory phenotype. Pericyte Tie2 controls sprouting angiogenesis in in vitro sprouting and in vivo spheroid assays. Tie2 downstream signalling in pericytes involves Calpain, Akt and FOXO3A. Ng2-Cre-driven deletion of pericyte-expressed Tie2 in mice transiently delays postnatal retinal angiogenesis. Yet, Tie2 deletion in pericytes results in a pronounced pro-angiogenic effect leading to enhanced tumour growth. Together, the data expand and revise the current concepts on vascular Angiopoietin/Tie signalling and propose a bidirectional, reciprocal EC-pericyte model of Tie2 signalling.
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000125298 7001_ $$0P:(DE-He78)f003032f4174166182cbb6e9e00e7839$$aMilde, Laura$$b1$$udkfz
000125298 7001_ $$0P:(DE-HGF)0$$aHolm, Annegret$$b2
000125298 7001_ $$0P:(DE-HGF)0$$aStanicek, Laura$$b3
000125298 7001_ $$0P:(DE-He78)d2851af71b2aced0c34d8c71329c3bc5$$aGengenbacher, Nicolas$$b4$$udkfz
000125298 7001_ $$0P:(DE-HGF)0$$aSavant, Soniya$$b5
000125298 7001_ $$0P:(DE-He78)506e027e02bbc385e5035a83ed1d8457$$aRuckdeschel, Tina$$b6$$udkfz
000125298 7001_ $$0P:(DE-He78)133dd4775ba44c855b8725bd4fba11b7$$aHasanov, Zulfiyya$$b7$$udkfz
000125298 7001_ $$0P:(DE-He78)68be8daf09675910338d6eca0149b182$$aSrivastava, Kshitij$$b8$$udkfz
000125298 7001_ $$0P:(DE-HGF)0$$aHu, Junhao$$b9
000125298 7001_ $$0P:(DE-He78)d460d1186cc2221a900505030de5029d$$aHertel, Stella$$b10$$udkfz
000125298 7001_ $$0P:(DE-HGF)0$$aBartol, Arne$$b11
000125298 7001_ $$0P:(DE-He78)e674edaa6403c4ef34b2fae4649e654f$$aSchlereth, Katharina$$b12$$udkfz
000125298 7001_ $$00000-0002-7173-4242$$aAugustin, Hellmut G$$b13$$eLast author
000125298 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms16106$$gVol. 8, p. 16106 -$$p16106 -$$tNature Communications$$v8$$x2041-1723$$y2017
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