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@ARTICLE{Teichert:125298,
      author       = {M. Teichert$^*$ and L. Milde$^*$ and A. Holm$^*$ and L.
                      Stanicek$^*$ and N. Gengenbacher$^*$ and S. Savant$^*$ and
                      T. Ruckdeschel$^*$ and Z. Hasanov$^*$ and K. Srivastava$^*$
                      and J. Hu$^*$ and S. Hertel$^*$ and A. Bartol$^*$ and K.
                      Schlereth$^*$ and H. G. Augustin$^*$},
      title        = {{P}ericyte-expressed {T}ie2 controls angiogenesis and
                      vessel maturation.},
      journal      = {Nature Communications},
      volume       = {8},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-01436},
      pages        = {16106 -},
      year         = {2017},
      abstract     = {The Tie receptors with their Angiopoietin ligands act as
                      regulators of angiogenesis and vessel maturation. Tie2
                      exerts its functions through its supposed
                      endothelial-specific expression. Yet, Tie2 is also expressed
                      at lower levels by pericytes and it has not been unravelled
                      through which mechanisms pericyte Angiopoietin/Tie
                      signalling affects angiogenesis. Here we show that human and
                      murine pericytes express functional Tie2 receptor. Silencing
                      of Tie2 in pericytes results in a pro-migratory phenotype.
                      Pericyte Tie2 controls sprouting angiogenesis in in vitro
                      sprouting and in vivo spheroid assays. Tie2 downstream
                      signalling in pericytes involves Calpain, Akt and FOXO3A.
                      Ng2-Cre-driven deletion of pericyte-expressed Tie2 in mice
                      transiently delays postnatal retinal angiogenesis. Yet, Tie2
                      deletion in pericytes results in a pronounced pro-angiogenic
                      effect leading to enhanced tumour growth. Together, the data
                      expand and revise the current concepts on vascular
                      Angiopoietin/Tie signalling and propose a bidirectional,
                      reciprocal EC-pericyte model of Tie2 signalling.},
      cin          = {A190},
      ddc          = {500},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28719590},
      pmc          = {pmc:PMC5520106},
      doi          = {10.1038/ncomms16106},
      url          = {https://inrepo02.dkfz.de/record/125298},
}