%0 Journal Article
%A Glemser, Philip Alexander
%A Jaeger, Heike
%A M Nagel, Armin
%A E Ziegler, Andreas
%A Simons, David
%A Schlemmer, Heinz-Peter
%A Lehmann-Horn, Frank
%A Jurkat-Rott, Karin
%A Weber, Marc-André
%T (23)Na MRI and myometry to compare eplerenone vs. glucocorticoid treatment in Duchenne dystrophy.
%J Acta myologica
%V 36
%N 1
%@ 1128-2460
%C Ospedaletto (PI)
%I Pacini
%M DKFZ-2017-01463
%P 2-13
%D 2017
%X In this pilot study we tested whether a low dose application of a mild diuretic substance such as eplerenone is beneficial in early stages of Duchenne muscular dystrophy using (23)Na und (1)H imaging, myometry, and clinical testing versus the glucocorticoid gold standard. Two 7-years old patients with DMD were examined on a 3T MRI system. (1)H MRI and (23)Na density-adapted 3-dimensional radial MRI sequences were performed both before and 1, 3 and 6 months after therapy with eplerenone respectively cortisone. We quantified fatty infiltration on T1-weighted images using subcutaneous fat as reference and fat fraction with a two-point DIXON sequence. Muscle oedema was quantified on STIR images and DIXON water maps with background noise as reference. We quantified Na(+) by a muscular tissue concentration sequence with a 51.3mM Na(+) with 5
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28690388
%2 pmc:PMC5479105
%U https://inrepo02.dkfz.de/record/125330