TY  - JOUR
AU  - Glemser, Philip Alexander
AU  - Jaeger, Heike
AU  - M Nagel, Armin
AU  - E Ziegler, Andreas
AU  - Simons, David
AU  - Schlemmer, Heinz-Peter
AU  - Lehmann-Horn, Frank
AU  - Jurkat-Rott, Karin
AU  - Weber, Marc-André
TI  - (23)Na MRI and myometry to compare eplerenone vs. glucocorticoid treatment in Duchenne dystrophy.
JO  - Acta myologica
VL  - 36
IS  - 1
SN  - 1128-2460
CY  - Ospedaletto (PI)
PB  - Pacini
M1  - DKFZ-2017-01463
SP  - 2-13
PY  - 2017
AB  - In this pilot study we tested whether a low dose application of a mild diuretic substance such as eplerenone is beneficial in early stages of Duchenne muscular dystrophy using (23)Na und (1)H imaging, myometry, and clinical testing versus the glucocorticoid gold standard. Two 7-years old patients with DMD were examined on a 3T MRI system. (1)H MRI and (23)Na density-adapted 3-dimensional radial MRI sequences were performed both before and 1, 3 and 6 months after therapy with eplerenone respectively cortisone. We quantified fatty infiltration on T1-weighted images using subcutaneous fat as reference and fat fraction with a two-point DIXON sequence. Muscle oedema was quantified on STIR images and DIXON water maps with background noise as reference. We quantified Na(+) by a muscular tissue concentration sequence with a 51.3mM Na(+) with 5
LB  - PUB:(DE-HGF)16
C6  - pmid:28690388
C2  - pmc:PMC5479105
UR  - https://inrepo02.dkfz.de/record/125330
ER  -