% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Glemser:125330,
      author       = {P. A. Glemser$^*$ and H. Jaeger and A. M Nagel$^*$ and A. E
                      Ziegler and D. Simons$^*$ and H.-P. Schlemmer$^*$ and F.
                      Lehmann-Horn and K. Jurkat-Rott and M.-A. Weber},
      title        = {(23){N}a {MRI} and myometry to compare eplerenone vs.
                      glucocorticoid treatment in {D}uchenne dystrophy.},
      journal      = {Acta myologica},
      volume       = {36},
      number       = {1},
      issn         = {1128-2460},
      address      = {Ospedaletto (PI)},
      publisher    = {Pacini},
      reportid     = {DKFZ-2017-01463},
      pages        = {2-13},
      year         = {2017},
      abstract     = {In this pilot study we tested whether a low dose
                      application of a mild diuretic substance such as eplerenone
                      is beneficial in early stages of Duchenne muscular dystrophy
                      using (23)Na und (1)H imaging, myometry, and clinical
                      testing versus the glucocorticoid gold standard. Two 7-years
                      old patients with DMD were examined on a 3T MRI system. (1)H
                      MRI and (23)Na density-adapted 3-dimensional radial MRI
                      sequences were performed both before and 1, 3 and 6 months
                      after therapy with eplerenone respectively cortisone. We
                      quantified fatty infiltration on T1-weighted images using
                      subcutaneous fat as reference and fat fraction with a
                      two-point DIXON sequence. Muscle oedema was quantified on
                      STIR images and DIXON water maps with background noise as
                      reference. We quantified Na(+) by a muscular tissue
                      concentration sequence with a 51.3mM Na(+) with $5\%$
                      agarose reference tube. A Na(+) IR-sequence was used for
                      determination of mainly myoplasmic Na(+). Correspondingly
                      myometry of muscles and tendons were assessed. Clinical
                      tests (i.e. 4-steps-test) and blood counts (i.e. K(+)) were
                      done by a pediatrician. Under eplerenone therapy we detected
                      a reduction of muscular oedema, intracellular-weighted
                      sodium IR signal and muscular sodium concentration. The
                      oedema reduction in the DMD patient receiving eplerenone was
                      more pronounced to the patient with cortisone.
                      Myometric-measured tissue parameters such as muscle
                      stiffness had a more pronounced effect in the child treated
                      with eplerenone after a first increase in muscle stiffness
                      both after eplerenone and cortisone treatment. Clinical
                      abilities during both therapies were mostly constant.
                      Eplerenone might be a possible new therapy option in DMD
                      patients.},
      cin          = {E010 / E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28690388},
      pmc          = {pmc:PMC5479105},
      url          = {https://inrepo02.dkfz.de/record/125330},
}