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000125342 1001_ $$aCheteh, Emarndeena H$$b0
000125342 245__ $$aHuman cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death.
000125342 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2017
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000125342 520__ $$aDrug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cancer cells on treatment with chemotherapeutic drugs. Co-culture with prostate CAFs or CAF-conditioned medium attenuated DNA damage and the p53 response to chemotherapeutic drugs and enhanced prostate cancer cell survival. CAF-conditioned medium inhibited the accumulation of doxorubicin, but not taxol, in prostate cancer cells in a manner that was associated with increased cancer cell glutathione levels. A low molecular weight fraction (<3 kDa) of CAF-conditioned medium had the same effect. CAF-conditioned medium also inhibited induction of reactive oxygen species (ROS) in both doxorubicin- and taxol-treated cancer cells. Our findings suggest that CAFs can enhance drug resistance in cancer cells by inhibiting drug accumulation and counteracting drug-induced oxidative stress. This protective mechanism may represent a novel therapeutic target in cancer.
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000125342 7001_ $$0P:(DE-He78)d05f6ed88b416dda3e27a7efe899b53f$$aAugsten, Martin$$b1$$udkfz
000125342 7001_ $$aRundqvist, Helene$$b2
000125342 7001_ $$aBianchi, Julie$$b3
000125342 7001_ $$aSarne, Victoria$$b4
000125342 7001_ $$aEgevad, Lars$$b5
000125342 7001_ $$aBykov, Vladimir Jn$$b6
000125342 7001_ $$aÖstman, Arne$$b7
000125342 7001_ $$aWiman, Klas G$$b8
000125342 773__ $$0PERI:(DE-600)2541626-1$$a10.1038/cddis.2017.225$$gVol. 8, no. 6, p. e2848 -$$n6$$pe2848 -$$tCell death & disease$$v8$$x2041-4889$$y2017
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000125342 9141_ $$y2017
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