% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Huhn:125360,
      author       = {K. Huhn and A. Mennecke and P. Linz and F. Tschunko and N.
                      Kästle and A. Nagel$^*$ and M. Uder and A. Dörfler and R.
                      A. Linker and T. Engelhorn},
      title        = {(23){N}a {MRI} reveals persistent sodium accumulation in
                      tumefactive {MS} lesions.},
      journal      = {Journal of the neurological sciences},
      volume       = {379},
      issn         = {0022-510X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-01493},
      pages        = {163 - 166},
      year         = {2017},
      abstract     = {Chronic inflammatory demyelinating diseases of the CNS
                      typically show a limited lesion size. However, extended
                      lesions may appear with an atypical configuration. Large
                      lesions with a diameter>2cm accompanied by tumor-like edema
                      are entitled 'tumefactive' and may occur in multiple
                      sclerosis (MS) and other demyelinating diseases.
                      Historically, differential diagnosis often requires
                      histological analysis. Therefore, advanced imaging
                      techniques are warranted to allow for a precise non-invasive
                      diagnosis. Cerebral sodium ((23)Na) MRI was recently
                      described as a new method to investigate in vivo sodium
                      accumulation. Indicating extended sodium levels in MS
                      lesions, (23)Na MRI is a promising differential diagnostic
                      tool further elucidating the role of sodium in demyelinating
                      lesions.Repetitive (23)Na MRI measurements in a MS patient
                      with a tumefactive demyelinating lesion providing insight
                      into the medium-term course of cerebral sodium levels.(23)Na
                      MRI depicts persistent lesional sodium accumulation after
                      anti-inflammatory treatment and provides the opportunity of
                      a non-invasive, in vivo analysis of sodium levels in
                      inflammatory CNS lesions without need for contrast enhancing
                      media. As a result of the extended dimension, tumefactive
                      lesions may have an appropriate size for the analysis of
                      inflammatory demyelination by (23)Na MRI with sufficient
                      resolution.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28716233},
      doi          = {10.1016/j.jns.2017.06.003},
      url          = {https://inrepo02.dkfz.de/record/125360},
}