000125369 001__ 125369
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000125369 0247_ $$2doi$$a10.1038/nature22973
000125369 0247_ $$2pmid$$apmid:28726821
000125369 0247_ $$2ISSN$$a0028-0836
000125369 0247_ $$2ISSN$$a1476-4687
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000125369 037__ $$aDKFZ-2017-01502
000125369 041__ $$aeng
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000125369 1001_ $$0P:(DE-HGF)0$$aNorthcott, Paul A$$b0$$eFirst author
000125369 245__ $$aThe whole-genome landscape of medulloblastoma subtypes.
000125369 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2017
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000125369 520__ $$aCurrent therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify the full spectrum of driver genes and molecular processes that operate in medulloblastoma subgroups. Here we analyse the somatic landscape across 491 sequenced medulloblastoma samples and the molecular heterogeneity among 1,256 epigenetically analysed cases, and identify subgroup-specific driver alterations that include previously undiscovered actionable targets. Driver mutations were confidently assigned to most patients belonging to Group 3 and Group 4 medulloblastoma subgroups, greatly enhancing previous knowledge. New molecular subtypes were differentially enriched for specific driver events, including hotspot in-frame insertions that target KBTBD4 and enhancer hijacking events that activate PRDM6. Thus, the application of integrative genomics to an extensive cohort of clinical samples derived from a single childhood cancer entity revealed a series of cancer genes and biologically relevant subtype diversity that represent attractive therapeutic targets for the treatment of patients with medulloblastoma.
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000125369 7001_ $$aMorrissy, A Sorana$$b2
000125369 7001_ $$0P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc$$aHovestadt, Volker$$b3
000125369 7001_ $$aWeischenfeldt, Joachim$$b4
000125369 7001_ $$aEhrenberger, Tobias$$b5
000125369 7001_ $$0P:(DE-He78)932918ed0e8d8790a81235528019a8e0$$aGröbner, Susanne$$b6
000125369 7001_ $$aSegura-Wang, Maia$$b7
000125369 7001_ $$aZichner, Thomas$$b8
000125369 7001_ $$aRudneva, Vasilisa A$$b9
000125369 7001_ $$aWarnatz, Hans-Jörg$$b10
000125369 7001_ $$aSidiropoulos, Nikos$$b11
000125369 7001_ $$aPhillips, Aaron H$$b12
000125369 7001_ $$aSchumacher, Steven$$b13
000125369 7001_ $$0P:(DE-He78)e053817bc90becc8a8dd8250e677e773$$aKleinheinz, Kortine$$b14
000125369 7001_ $$aWaszak, Sebastian M$$b15
000125369 7001_ $$0P:(DE-He78)df8660bc5aba525f7fb6dba4aac15c1c$$aErkek, Serap$$b16
000125369 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b17
000125369 7001_ $$0P:(DE-He78)fae1bf941c5fd76cf5356ecfa1243cc4$$aWorst, Barbara$$b18
000125369 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b19
000125369 7001_ $$0P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7$$aZapatka, Marc$$b20
000125369 7001_ $$0P:(DE-He78)bff9e3e3d86865d2b0836bb8f3ce98f3$$aJäger, Natalie$$b21
000125369 7001_ $$0P:(DE-HGF)0$$aChavez, Lukas$$b22
000125369 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b23
000125369 7001_ $$0P:(DE-He78)e247efc0264a7b0e4bae09804002d4e1$$aBieg, Matthias$$b24
000125369 7001_ $$0P:(DE-He78)4a8b73f9f05542860120bb0e19527fd2$$aParamasivam, Nagarajan$$b25
000125369 7001_ $$0P:(DE-He78)ae1b30b052ea4c3ea118a5ca3b46adc3$$aHeinold, Michael$$b26
000125369 7001_ $$0P:(DE-He78)73316f3cd41c27508dbb6f4c5e7e7a8a$$aGu, Zuguang$$b27
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000125369 7001_ $$0P:(DE-HGF)0$$aJäger-Schmidt, Christina$$b29
000125369 7001_ $$0P:(DE-HGF)0$$aImbusch, Charles D$$b30
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000125369 7001_ $$0P:(DE-HGF)0$$aHübschmann, Daniel$$b32
000125369 7001_ $$aRisch, Thomas$$b33
000125369 7001_ $$aAmstislavskiy, Vyacheslav$$b34
000125369 7001_ $$aGonzalez, Francisco German Rodriguez$$b35
000125369 7001_ $$0P:(DE-He78)4fbd3823a23414f37b9f1a445cad566e$$aWeber, Ursula$$b36
000125369 7001_ $$0P:(DE-He78)1efb774993effe7a66a6ffc1b1cf9ccb$$aWolf, Stephan$$b37
000125369 7001_ $$aRobinson, Giles W$$b38
000125369 7001_ $$aZhou, Xin$$b39
000125369 7001_ $$aWu, Gang$$b40
000125369 7001_ $$aFinkelstein, David$$b41
000125369 7001_ $$aLiu, Yanling$$b42
000125369 7001_ $$aCavalli, Florence M G$$b43
000125369 7001_ $$aLuu, Betty$$b44
000125369 7001_ $$aRamaswamy, Vijay$$b45
000125369 7001_ $$aWu, Xiaochong$$b46
000125369 7001_ $$aKoster, Jan$$b47
000125369 7001_ $$aRyzhova, Marina$$b48
000125369 7001_ $$aCho, Yoon-Jae$$b49
000125369 7001_ $$aPomeroy, Scott L$$b50
000125369 7001_ $$aHerold-Mende, Christel$$b51
000125369 7001_ $$aSchuhmann, Martin$$b52
000125369 7001_ $$aEbinger, Martin$$b53
000125369 7001_ $$aLiau, Linda M$$b54
000125369 7001_ $$aMora, Jaume$$b55
000125369 7001_ $$aMcLendon, Roger E$$b56
000125369 7001_ $$aJabado, Nada$$b57
000125369 7001_ $$aKumabe, Toshihiro$$b58
000125369 7001_ $$aChuah, Eric$$b59
000125369 7001_ $$aMa, Yussanne$$b60
000125369 7001_ $$aMoore, Richard A$$b61
000125369 7001_ $$aMungall, Andrew J$$b62
000125369 7001_ $$aMungall, Karen L$$b63
000125369 7001_ $$aThiessen, Nina$$b64
000125369 7001_ $$aTse, Kane$$b65
000125369 7001_ $$aWong, Tina$$b66
000125369 7001_ $$aJones, Steven J M$$b67
000125369 7001_ $$0P:(DE-He78)143af26de9d57bf624771616318aaf7c$$aWitt, Olaf$$b68
000125369 7001_ $$0P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f$$aMilde, Till$$b69
000125369 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$aVon Deimling, Andreas$$b70
000125369 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b71
000125369 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b72
000125369 7001_ $$aYaspo, Marie-Laure$$b73
000125369 7001_ $$aKriwacki, Richard$$b74
000125369 7001_ $$aGajjar, Amar$$b75
000125369 7001_ $$aZhang, Jinghui$$b76
000125369 7001_ $$aBeroukhim, Rameen$$b77
000125369 7001_ $$aFraenkel, Ernest$$b78
000125369 7001_ $$aKorbel, Jan O$$b79
000125369 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b80
000125369 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b81
000125369 7001_ $$0P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0$$aEils, Roland$$b82
000125369 7001_ $$aMarra, Marco A$$b83
000125369 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b84
000125369 7001_ $$aTaylor, Michael D$$b85
000125369 7001_ $$0P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c$$aLichter, Peter$$b86$$eLast author
000125369 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/nature22973$$gVol. 547, no. 7663, p. 311 - 317$$n7663$$p311 - 317$$tNature <London>$$v547$$x1476-4687$$y2017
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