TY  - JOUR
AU  - Northcott, Paul A
AU  - Buchhalter, Ivo
AU  - Morrissy, A Sorana
AU  - Hovestadt, Volker
AU  - Weischenfeldt, Joachim
AU  - Ehrenberger, Tobias
AU  - Gröbner, Susanne
AU  - Segura-Wang, Maia
AU  - Zichner, Thomas
AU  - Rudneva, Vasilisa A
AU  - Warnatz, Hans-Jörg
AU  - Sidiropoulos, Nikos
AU  - Phillips, Aaron H
AU  - Schumacher, Steven
AU  - Kleinheinz, Kortine
AU  - Waszak, Sebastian M
AU  - Erkek, Serap
AU  - Jones, David
AU  - Worst, Barbara
AU  - Kool, Marcel
AU  - Zapatka, Marc
AU  - Jäger, Natalie
AU  - Chavez, Lukas
AU  - Hutter, Barbara
AU  - Bieg, Matthias
AU  - Paramasivam, Nagarajan
AU  - Heinold, Michael
AU  - Gu, Zuguang
AU  - Ishaque, Naveed
AU  - Jäger-Schmidt, Christina
AU  - Imbusch, Charles D
AU  - Jugold, Alke
AU  - Hübschmann, Daniel
AU  - Risch, Thomas
AU  - Amstislavskiy, Vyacheslav
AU  - Gonzalez, Francisco German Rodriguez
AU  - Weber, Ursula
AU  - Wolf, Stephan
AU  - Robinson, Giles W
AU  - Zhou, Xin
AU  - Wu, Gang
AU  - Finkelstein, David
AU  - Liu, Yanling
AU  - Cavalli, Florence M G
AU  - Luu, Betty
AU  - Ramaswamy, Vijay
AU  - Wu, Xiaochong
AU  - Koster, Jan
AU  - Ryzhova, Marina
AU  - Cho, Yoon-Jae
AU  - Pomeroy, Scott L
AU  - Herold-Mende, Christel
AU  - Schuhmann, Martin
AU  - Ebinger, Martin
AU  - Liau, Linda M
AU  - Mora, Jaume
AU  - McLendon, Roger E
AU  - Jabado, Nada
AU  - Kumabe, Toshihiro
AU  - Chuah, Eric
AU  - Ma, Yussanne
AU  - Moore, Richard A
AU  - Mungall, Andrew J
AU  - Mungall, Karen L
AU  - Thiessen, Nina
AU  - Tse, Kane
AU  - Wong, Tina
AU  - Jones, Steven J M
AU  - Witt, Olaf
AU  - Milde, Till
AU  - Von Deimling, Andreas
AU  - Capper, David
AU  - Korshunov, Andrey
AU  - Yaspo, Marie-Laure
AU  - Kriwacki, Richard
AU  - Gajjar, Amar
AU  - Zhang, Jinghui
AU  - Beroukhim, Rameen
AU  - Fraenkel, Ernest
AU  - Korbel, Jan O
AU  - Brors, Benedikt
AU  - Schlesner, Matthias
AU  - Eils, Roland
AU  - Marra, Marco A
AU  - Pfister, Stefan
AU  - Taylor, Michael D
AU  - Lichter, Peter
TI  - The whole-genome landscape of medulloblastoma subtypes.
JO  - Nature 
VL  - 547
IS  - 7663
SN  - 1476-4687
CY  - London [u.a.]
PB  - Nature Publ. Group
M1  - DKFZ-2017-01502
SP  - 311 - 317
PY  - 2017
AB  - Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify the full spectrum of driver genes and molecular processes that operate in medulloblastoma subgroups. Here we analyse the somatic landscape across 491 sequenced medulloblastoma samples and the molecular heterogeneity among 1,256 epigenetically analysed cases, and identify subgroup-specific driver alterations that include previously undiscovered actionable targets. Driver mutations were confidently assigned to most patients belonging to Group 3 and Group 4 medulloblastoma subgroups, greatly enhancing previous knowledge. New molecular subtypes were differentially enriched for specific driver events, including hotspot in-frame insertions that target KBTBD4 and enhancer hijacking events that activate PRDM6. Thus, the application of integrative genomics to an extensive cohort of clinical samples derived from a single childhood cancer entity revealed a series of cancer genes and biologically relevant subtype diversity that represent attractive therapeutic targets for the treatment of patients with medulloblastoma.
LB  - PUB:(DE-HGF)16
C6  - pmid:28726821
DO  - DOI:10.1038/nature22973
UR  - https://inrepo02.dkfz.de/record/125369
ER  -