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@ARTICLE{Northcott:125369,
      author       = {P. A. Northcott$^*$ and I. Buchhalter$^*$ and A. S.
                      Morrissy and V. Hovestadt$^*$ and J. Weischenfeldt and T.
                      Ehrenberger and S. Gröbner$^*$ and M. Segura-Wang and T.
                      Zichner and V. A. Rudneva and H.-J. Warnatz and N.
                      Sidiropoulos and A. H. Phillips and S. Schumacher and K.
                      Kleinheinz$^*$ and S. M. Waszak and S. Erkek$^*$ and D.
                      Jones$^*$ and B. Worst$^*$ and M. Kool$^*$ and M.
                      Zapatka$^*$ and N. Jäger$^*$ and L. Chavez$^*$ and B.
                      Hutter$^*$ and M. Bieg$^*$ and N. Paramasivam$^*$ and M.
                      Heinold$^*$ and Z. Gu$^*$ and N. Ishaque$^*$ and C.
                      Jäger-Schmidt and C. D. Imbusch and A. Jugold$^*$ and D.
                      Hübschmann$^*$ and T. Risch and V. Amstislavskiy and F. G.
                      R. Gonzalez and U. Weber$^*$ and S. Wolf$^*$ and G. W.
                      Robinson and X. Zhou and G. Wu and D. Finkelstein and Y. Liu
                      and F. M. G. Cavalli and B. Luu and V. Ramaswamy and X. Wu
                      and J. Koster and M. Ryzhova and Y.-J. Cho and S. L. Pomeroy
                      and C. Herold-Mende and M. Schuhmann and M. Ebinger and L.
                      M. Liau and J. Mora and R. E. McLendon and N. Jabado and T.
                      Kumabe and E. Chuah and Y. Ma and R. A. Moore and A. J.
                      Mungall and K. L. Mungall and N. Thiessen and K. Tse and T.
                      Wong and S. J. M. Jones and O. Witt$^*$ and T. Milde$^*$ and
                      A. Von Deimling$^*$ and D. Capper$^*$ and A. Korshunov$^*$
                      and M.-L. Yaspo and R. Kriwacki and A. Gajjar and J. Zhang
                      and R. Beroukhim and E. Fraenkel and J. O. Korbel and B.
                      Brors$^*$ and M. Schlesner$^*$ and R. Eils$^*$ and M. A.
                      Marra and S. Pfister$^*$ and M. D. Taylor and P.
                      Lichter$^*$},
      title        = {{T}he whole-genome landscape of medulloblastoma subtypes.},
      journal      = {Nature},
      volume       = {547},
      number       = {7663},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-01502},
      pages        = {311 - 317},
      year         = {2017},
      abstract     = {Current therapies for medulloblastoma, a highly malignant
                      childhood brain tumour, impose debilitating effects on the
                      developing child, and highlight the need for molecularly
                      targeted treatments with reduced toxicity. Previous studies
                      have been unable to identify the full spectrum of driver
                      genes and molecular processes that operate in
                      medulloblastoma subgroups. Here we analyse the somatic
                      landscape across 491 sequenced medulloblastoma samples and
                      the molecular heterogeneity among 1,256 epigenetically
                      analysed cases, and identify subgroup-specific driver
                      alterations that include previously undiscovered actionable
                      targets. Driver mutations were confidently assigned to most
                      patients belonging to Group 3 and Group 4 medulloblastoma
                      subgroups, greatly enhancing previous knowledge. New
                      molecular subtypes were differentially enriched for specific
                      driver events, including hotspot in-frame insertions that
                      target KBTBD4 and enhancer hijacking events that activate
                      PRDM6. Thus, the application of integrative genomics to an
                      extensive cohort of clinical samples derived from a single
                      childhood cancer entity revealed a series of cancer genes
                      and biologically relevant subtype diversity that represent
                      attractive therapeutic targets for the treatment of patients
                      with medulloblastoma.},
      cin          = {B062 / B080 / G200 / B060 / L101 / W190},
      ddc          = {070},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B080-20160331 /
                      I:(DE-He78)G200-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)W190-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28726821},
      doi          = {10.1038/nature22973},
      url          = {https://inrepo02.dkfz.de/record/125369},
}