000125384 001__ 125384
000125384 005__ 20240228145526.0
000125384 0247_ $$2doi$$a10.1007/s00520-017-3694-8
000125384 0247_ $$2pmid$$apmid:28417202
000125384 0247_ $$2ISSN$$a0941-4355
000125384 0247_ $$2ISSN$$a1433-7339
000125384 0247_ $$2altmetric$$aaltmetric:19187500
000125384 037__ $$aDKFZ-2017-01514
000125384 041__ $$aeng
000125384 082__ $$a610
000125384 1001_ $$0P:(DE-He78)f52b77d7ab843c9b900134aafc61638a$$aClauss, Dorothea$$b0$$eFirst author$$udkfz
000125384 245__ $$aCardiorespiratory fitness and muscle strength in pancreatic cancer patients.
000125384 260__ $$aBerlin$$bSpringer$$c2017
000125384 3367_ $$2DRIVER$$aarticle
000125384 3367_ $$2DataCite$$aOutput Types/Journal article
000125384 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1510051590_26476
000125384 3367_ $$2BibTeX$$aARTICLE
000125384 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000125384 3367_ $$00$$2EndNote$$aJournal Article
000125384 520__ $$aCancer patients frequently experience reduced physical fitness due to the disease itself as well as treatment-related side effects. However, studies on physical fitness in pancreatic cancer patients are missing. Therefore, we assessed cardiorespiratory fitness and muscle strength of pancreatic cancer patients.We included 65 pancreatic cancer patients, mostly after surgical resection. Cardiorespiratory fitness was assessed using cardiopulmonary exercise testing (CPET) and 6-min walk test (6MWT). Hand-held dynamometry was used to evaluate isometric muscle strength. Physical fitness values were compared to reference values of a healthy population. Associations between sociodemographic and clinical variables with patients' physical fitness were analyzed using multiple regression models.Cardiorespiratory fitness (VO2peak, 20.5 ± 6.9 ml/min/kg) was significantly lower (-24%) compared to healthy reference values. In the 6MWT pancreatic cancer patients nearly reached predicted values (555 vs. 562 m). Maximal voluntary isometric contraction (MVIC) of the upper (-4.3%) and lower extremities (-13.8%) were significantly lower compared to reference values. Overall differences were larger in men than those in women. Participating in regular exercise in the year before diagnosis was associated with greater VO2peak (p < .05) and MVIC of the knee extensors (p < .05).Pancreatic cancer patients had significantly impaired physical fitness with regard to both cardiorespiratory function and isometric muscle strength, already in the early treatment phase (median 95 days after surgical resection). Our findings underline the need to investigate exercise training in pancreatic cancer patients to counteract the loss of physical fitness.
000125384 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000125384 588__ $$aDataset connected to CrossRef, PubMed,
000125384 7001_ $$aTjaden, Christine$$b1
000125384 7001_ $$aHackert, Thilo$$b2
000125384 7001_ $$aSchneider, Lutz$$b3
000125384 7001_ $$0P:(DE-HGF)0$$aUlrich, Cornelia M$$b4
000125384 7001_ $$0P:(DE-He78)60b584aeef81e4c57fd111fa63779b73$$aWiskemann, Joachim$$b5$$udkfz
000125384 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b6$$eLast author$$udkfz
000125384 773__ $$0PERI:(DE-600)1463166-0$$a10.1007/s00520-017-3694-8$$gVol. 25, no. 9, p. 2797 - 2807$$n9$$p2797 - 2807$$tSupportive care in cancer$$v25$$x1433-7339$$y2017
000125384 909CO $$ooai:inrepo02.dkfz.de:125384$$pVDB
000125384 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f52b77d7ab843c9b900134aafc61638a$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000125384 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000125384 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)60b584aeef81e4c57fd111fa63779b73$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000125384 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000125384 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000125384 9141_ $$y2017
000125384 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000125384 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000125384 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000125384 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000125384 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSUPPORT CARE CANCER : 2015
000125384 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000125384 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000125384 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000125384 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000125384 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000125384 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000125384 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000125384 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000125384 9201_ $$0I:(DE-He78)G210-20160331$$kG210$$lBewegung, Präventionsforschung und Krebs$$x0
000125384 980__ $$ajournal
000125384 980__ $$aVDB
000125384 980__ $$aI:(DE-He78)G210-20160331
000125384 980__ $$aUNRESTRICTED