% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Thierauf:125397,
      author       = {J. Thierauf and J. A. Veit and J. Hess$^*$},
      title        = {{E}pithelial-to-{M}esenchymal {T}ransition in the
                      {P}athogenesis and {T}herapy of {H}ead and {N}eck {C}ancer.},
      journal      = {Cancers},
      volume       = {9},
      number       = {7},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2017-01527},
      pages        = {76},
      year         = {2017},
      abstract     = {Head and neck cancer (HNC) is one of the most prevalent
                      human malignancies worldwide, with a high morbidity and
                      mortality. Implementation of interdisciplinary treatment
                      modalities has improved the quality of life, but only minor
                      changes in overall survival have been achieved over the past
                      decades. Main causes for treatment failure are an aggressive
                      and invasive tumor growth in combination with a high degree
                      of intrinsic or acquired treatment resistance. A subset of
                      tumor cells gain these properties during malignant
                      progression by reactivating a complex program of
                      epithelia-to-mesenchymal transition (EMT), which is integral
                      in embryonic development, wound healing, and stem cell
                      behavior. EMT is mediated by a core set of key transcription
                      factors, which are under the control of a large range of
                      developmental signals and extracellular cues. Unraveling
                      molecular principles that drive EMT provides new concepts to
                      better understand tumor cell plasticity and response to
                      established as well as new treatment modalities, and has the
                      potential to identify new drug targets for a more effective,
                      less toxic, and individualized therapy of HNC patients.
                      Here, we review the most recent findings on the clinical
                      relevance of a mesenchymal-like phenotype for HNC patients,
                      including more rare cases of mucosal melanoma and adenoid
                      cystic carcinoma.},
      subtyp        = {Review Article},
      cin          = {G405},
      ddc          = {610},
      cid          = {I:(DE-He78)G405-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28671620},
      pmc          = {pmc:PMC5532612},
      doi          = {10.3390/cancers9070076},
      url          = {https://inrepo02.dkfz.de/record/125397},
}