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000125485 1001_ $$00000-0002-4961-3639$$aBauer, Tobias$$b0$$eFirst author
000125485 245__ $$aEnvironment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.
000125485 260__ $$aHeidelberg$$bEMBO Press$$c2016
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000125485 520__ $$aEpigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype-related DNA methylation changes. Differential methylation is enriched in enhancer elements and targets in particular 'commuting' enhancers having multiple, regulatory interactions with distal genes. Longitudinal whole-genome bisulfite sequencing revealed that DNA methylation changes associated with maternal smoking persist over years of life. Particularly in children prenatal environmental exposure leads to chromatin transitions into a hyperactive state. Combined DNA methylation, histone modification, and gene expression analyses indicate that differential methylation in enhancer regions is more often functionally translated than methylation changes in promoters or non-regulatory elements. Finally, we show that epigenetic deregulation of a commuting enhancer targeting c-Jun N-terminal kinase 2 (JNK2) is linked to impaired lung function in early childhood.
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000125485 650_7 $$2NLM Chemicals$$aChromatin
000125485 650_7 $$2NLM Chemicals$$aHistones
000125485 650_7 $$0EC 2.7.1.24$$2NLM Chemicals$$aMitogen-Activated Protein Kinase 9
000125485 7001_ $$aTrump, Saskia$$b1
000125485 7001_ $$0P:(DE-He78)4096eeffdfc73b75e8ba63dc621a017d$$aIshaque, Naveed$$b2$$udkfz
000125485 7001_ $$aThürmann, Loreen$$b3
000125485 7001_ $$aGu, Lei$$b4
000125485 7001_ $$aBauer, Mario$$b5
000125485 7001_ $$0P:(DE-He78)e247efc0264a7b0e4bae09804002d4e1$$aBieg, Matthias$$b6$$udkfz
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000125485 7001_ $$0P:(DE-He78)697cb039ca08f3b7e5a2a52dbf020b46$$aMallm, Jan-Philipp$$b9$$udkfz
000125485 7001_ $$aRöder, Stefan$$b10
000125485 7001_ $$aHerberth, Gunda$$b11
000125485 7001_ $$aTakada, Eiko$$b12
000125485 7001_ $$0P:(DE-He78)aaef108f2a1ba0a78fff60ac60d3368c$$aMücke, Oliver$$b13$$udkfz
000125485 7001_ $$aWinter, Marcus$$b14
000125485 7001_ $$aJunge, Kristin M$$b15
000125485 7001_ $$aGrützmann, Konrad$$b16
000125485 7001_ $$aRolle-Kampczyk, Ulrike$$b17
000125485 7001_ $$0P:(DE-HGF)0$$aWang, Qi$$b18
000125485 7001_ $$0P:(DE-He78)5398550c21bc4ce3b0ff670b04150334$$aLawerenz, Christian$$b19$$udkfz
000125485 7001_ $$aBorte, Michael$$b20
000125485 7001_ $$aPolte, Tobias$$b21
000125485 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b22$$udkfz
000125485 7001_ $$0P:(DE-He78)7ec2e98d8e1badc97076e799a99f5a38$$aSchanne, Michaela$$b23$$udkfz
000125485 7001_ $$0P:(DE-He78)f6bebe05e7a748d3cbf9f59659567d52$$aWiemann, Stefan$$b24$$udkfz
000125485 7001_ $$0P:(DE-He78)3f888debb126ff36634df058ccaaf2b4$$aGeörg, Christina$$b25$$udkfz
000125485 7001_ $$aStunnenberg, Hendrik G$$b26
000125485 7001_ $$0P:(DE-He78)4301875630bc997edf491c694ae1f8a9$$aPlass, Christoph$$b27$$udkfz
000125485 7001_ $$0P:(DE-He78)94de5f7413279464b6e738d91dfae1eb$$aRippe, Karsten$$b28$$udkfz
000125485 7001_ $$aMizuguchi, Junichiro$$b29
000125485 7001_ $$0P:(DE-He78)be4a5aeed7282c071b3ff43e9685c48c$$aHerrmann, Carl$$b30$$udkfz
000125485 7001_ $$00000-0002-0034-4036$$aEils, Roland$$b31
000125485 7001_ $$aLehmann, Irina$$b32
000125485 773__ $$0PERI:(DE-600)2193510-5$$gVol. 12, no. 3$$n3$$p861$$tMolecular systems biology$$v12$$x1744-4292$$y2016
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