% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Bauer:125485,
      author       = {T. Bauer$^*$ and S. Trump and N. Ishaque$^*$ and L.
                      Thürmann and L. Gu and M. Bauer and M. Bieg$^*$ and Z.
                      Gu$^*$ and D. Weichenhan$^*$ and J.-P. Mallm$^*$ and S.
                      Röder and G. Herberth and E. Takada and O. Mücke$^*$ and
                      M. Winter and K. M. Junge and K. Grützmann and U.
                      Rolle-Kampczyk and Q. Wang$^*$ and C. Lawerenz$^*$ and M.
                      Borte and T. Polte and M. Schlesner$^*$ and M. Schanne$^*$
                      and S. Wiemann$^*$ and C. Geörg$^*$ and H. G. Stunnenberg
                      and C. Plass$^*$ and K. Rippe$^*$ and J. Mizuguchi and C.
                      Herrmann$^*$ and R. Eils$^*$ and I. Lehmann},
      title        = {{E}nvironment-induced epigenetic reprogramming in genomic
                      regulatory elements in smoking mothers and their children.},
      journal      = {Molecular systems biology},
      volume       = {12},
      number       = {3},
      issn         = {1744-4292},
      address      = {Heidelberg},
      publisher    = {EMBO Press},
      reportid     = {DKFZ-2017-01611},
      pages        = {861},
      year         = {2016},
      abstract     = {Epigenetic mechanisms have emerged as links between
                      prenatal environmental exposure and disease risk later in
                      life. Here, we studied epigenetic changes associated with
                      maternal smoking at base pair resolution by mapping DNA
                      methylation, histone modifications, and transcription in
                      expectant mothers and their newborn children. We found
                      extensive global differential methylation and carefully
                      evaluated these changes to separate environment associated
                      from genotype-related DNA methylation changes. Differential
                      methylation is enriched in enhancer elements and targets in
                      particular 'commuting' enhancers having multiple, regulatory
                      interactions with distal genes. Longitudinal whole-genome
                      bisulfite sequencing revealed that DNA methylation changes
                      associated with maternal smoking persist over years of life.
                      Particularly in children prenatal environmental exposure
                      leads to chromatin transitions into a hyperactive state.
                      Combined DNA methylation, histone modification, and gene
                      expression analyses indicate that differential methylation
                      in enhancer regions is more often functionally translated
                      than methylation changes in promoters or non-regulatory
                      elements. Finally, we show that epigenetic deregulation of a
                      commuting enhancer targeting c-Jun N-terminal kinase 2
                      (JNK2) is linked to impaired lung function in early
                      childhood.},
      keywords     = {Chromatin (NLM Chemicals) / Histones (NLM Chemicals) /
                      Mitogen-Activated Protein Kinase 9 (NLM Chemicals)},
      cin          = {B080 / C010 / W190 / W110 / B050 / B066},
      ddc          = {570},
      cid          = {I:(DE-He78)B080-20160331 / I:(DE-He78)C010-20160331 /
                      I:(DE-He78)W190-20160331 / I:(DE-He78)W110-20160331 /
                      I:(DE-He78)B050-20160331 / I:(DE-He78)B066-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27013061},
      pmc          = {pmc:PMC4812527},
      url          = {https://inrepo02.dkfz.de/record/125485},
}