% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Bender:125497,
      author       = {S. Bender$^*$ and J. Gronych and H.-J. Warnatz and B.
                      Hutter$^*$ and S. Gröbner and M. Ryzhova and E. Pfaff$^*$
                      and V. Hovestadt and F. Weinberg and S. Halbach and M.
                      Kool$^*$ and P. A. Northcott and D. Sturm and L. Bjerke and
                      T. Zichner and A. M. Stütz and K. Schramm and B. Huang and
                      I. Buchhalter$^*$ and M. Heinold$^*$ and T. Risch and B. C.
                      Worst and C. M. van Tilburg and U. D. Weber and M.
                      Zapatka$^*$ and B. Raeder and D. Milford and S. Heiland and
                      C. von Kalle$^*$ and C. Previti and C. Lawerenz$^*$ and A.
                      E. Kulozik and A. Unterberg and O. Witt$^*$ and A. von
                      Deimling$^*$ and D. Capper$^*$ and N. Truffaux and J. Grill
                      and N. Jabado and A. M. Sehested and D. Sumerauer and D. H.
                      Brahim and S. Trabelsi and H.-K. Ng and D. Zagzag and J. C.
                      Allen and M. A. Karajannis and N. G. Gottardo and C. Jones
                      and J. O. Korbel and S. Schmidt$^*$ and S. Wolf$^*$ and G.
                      Reifenberger and J. Felsberg and B. Brors$^*$ and C.
                      Herold-Mende and H. Lehrach and T. Brummer and A. Korshunov
                      and R. Eils$^*$ and M.-L. Yaspo and S. Pfister$^*$ and P.
                      Lichter$^*$ and D. Jones$^*$},
      collaboration = {, , International Cancer Genome Consortium PedBrain Tumor
                      Project.},
      title        = {{R}ecurrent {MET} fusion genes represent a drug target in
                      pediatric glioblastoma.},
      journal      = {Nature medicine},
      volume       = {22},
      number       = {11},
      issn         = {1546-170X},
      address      = {New York, NY},
      publisher    = {Nature America Inc.},
      reportid     = {DKFZ-2017-01623},
      pages        = {1314 - 1320},
      year         = {2016},
      note         = {Bender S*, Gronych J*, Warnatz HJ*, Hutter B*(*shared first
                      and senior authorships)Pfister SM*, Lichter P*, Jones DT*},
      abstract     = {Pediatric glioblastoma is one of the most common and most
                      deadly brain tumors in childhood. Using an integrative
                      genetic analysis of 53 pediatric glioblastomas and five in
                      vitro model systems, we identified previously unidentified
                      gene fusions involving the MET oncogene in $∼10\%$ of
                      cases. These MET fusions activated mitogen-activated protein
                      kinase (MAPK) signaling and, in cooperation with lesions
                      compromising cell cycle regulation, induced aggressive glial
                      tumors in vivo. MET inhibitors suppressed MET tumor growth
                      in xenograft models. Finally, we treated a pediatric patient
                      bearing a MET-fusion-expressing glioblastoma with the
                      targeted inhibitor crizotinib. This therapy led to
                      substantial tumor shrinkage and associated relief of
                      symptoms, but new treatment-resistant lesions appeared,
                      indicating that combination therapies are likely necessary
                      to achieve a durable clinical response.},
      keywords     = {Anilides (NLM Chemicals) / DNA, Neoplasm (NLM Chemicals) /
                      GSK 1363089 (NLM Chemicals) / Microtubule-Associated
                      Proteins (NLM Chemicals) / Oncogene Proteins, Fusion (NLM
                      Chemicals) / Protein Kinase Inhibitors (NLM Chemicals) /
                      Proteins (NLM Chemicals) / Pyrazoles (NLM Chemicals) /
                      Pyridines (NLM Chemicals) / Quinolines (NLM Chemicals) /
                      RNA, Messenger (NLM Chemicals) / TFG protein, human (NLM
                      Chemicals) / cytoplasmic linker protein 115 (NLM Chemicals)
                      / crizotinib (NLM Chemicals) / Proto-Oncogene Proteins c-met
                      (NLM Chemicals) / Mitogen-Activated Protein Kinases (NLM
                      Chemicals) / PTPRZ1 protein, human (NLM Chemicals) /
                      Receptor-Like Protein Tyrosine Phosphatases, Class 5 (NLM
                      Chemicals)},
      cin          = {G100 / G200 / B062 / B060 / G010 / G340 / G380 / W190 /
                      B080 / L101 / L601 / L401},
      ddc          = {610},
      cid          = {I:(DE-He78)G100-20160331 / I:(DE-He78)G200-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)G010-20160331 / I:(DE-He78)G340-20160331 /
                      I:(DE-He78)G380-20160331 / I:(DE-He78)W190-20160331 /
                      I:(DE-He78)B080-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)L601-20160331 / I:(DE-He78)L401-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27748748},
      doi          = {10.1038/nm.4204},
      url          = {https://inrepo02.dkfz.de/record/125497},
}