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| 001 | 125497 | ||
| 005 | 20240228143311.0 | ||
| 024 | 7 | _ | |a 10.1038/nm.4204 |2 doi |
| 024 | 7 | _ | |a pmid:27748748 |2 pmid |
| 024 | 7 | _ | |a 1078-8956 |2 ISSN |
| 024 | 7 | _ | |a 1546-170X |2 ISSN |
| 024 | 7 | _ | |a altmetric:12683505 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-01623 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bender, Sebastian |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. |
| 260 | _ | _ | |a New York, NY |c 2016 |b Nature America Inc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521722486_15724 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Bender S*, Gronych J*, Warnatz HJ*, Hutter B*(*shared first and senior authorships)Pfister SM*, Lichter P*, Jones DT* |
| 520 | _ | _ | |a Pediatric glioblastoma is one of the most common and most deadly brain tumors in childhood. Using an integrative genetic analysis of 53 pediatric glioblastomas and five in vitro model systems, we identified previously unidentified gene fusions involving the MET oncogene in ∼10% of cases. These MET fusions activated mitogen-activated protein kinase (MAPK) signaling and, in cooperation with lesions compromising cell cycle regulation, induced aggressive glial tumors in vivo. MET inhibitors suppressed MET tumor growth in xenograft models. Finally, we treated a pediatric patient bearing a MET-fusion-expressing glioblastoma with the targeted inhibitor crizotinib. This therapy led to substantial tumor shrinkage and associated relief of symptoms, but new treatment-resistant lesions appeared, indicating that combination therapies are likely necessary to achieve a durable clinical response. |
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| 650 | _ | 7 | |a Anilides |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA, Neoplasm |2 NLM Chemicals |
| 650 | _ | 7 | |a GSK 1363089 |2 NLM Chemicals |
| 650 | _ | 7 | |a Microtubule-Associated Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Oncogene Proteins, Fusion |2 NLM Chemicals |
| 650 | _ | 7 | |a Protein Kinase Inhibitors |2 NLM Chemicals |
| 650 | _ | 7 | |a Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Pyrazoles |2 NLM Chemicals |
| 650 | _ | 7 | |a Pyridines |2 NLM Chemicals |
| 650 | _ | 7 | |a Quinolines |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA, Messenger |2 NLM Chemicals |
| 650 | _ | 7 | |a TFG protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a cytoplasmic linker protein 115 |2 NLM Chemicals |
| 650 | _ | 7 | |a crizotinib |0 53AH36668S |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins c-met |0 EC 2.7.10.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Mitogen-Activated Protein Kinases |0 EC 2.7.11.24 |2 NLM Chemicals |
| 650 | _ | 7 | |a PTPRZ1 protein, human |0 EC 3.1.3.48 |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor-Like Protein Tyrosine Phosphatases, Class 5 |0 EC 3.1.3.48 |2 NLM Chemicals |
| 700 | 1 | _ | |a Gronych, Jan |0 0000-0003-0557-679X |b 1 |
| 700 | 1 | _ | |a Warnatz, Hans-Jörg |0 0000-0002-0327-9209 |b 2 |
| 700 | 1 | _ | |a Hutter, Barbara |0 0000-0002-9034-0329 |b 3 |e First author |
| 700 | 1 | _ | |a Gröbner, Susanne |b 4 |
| 700 | 1 | _ | |a Ryzhova, Marina |b 5 |
| 700 | 1 | _ | |a Pfaff, Elke |0 P:(DE-He78)c0538fae462bd98e3cd8d54ed885b0eb |b 6 |
| 700 | 1 | _ | |a Hovestadt, Volker |b 7 |
| 700 | 1 | _ | |a Weinberg, Florian |b 8 |
| 700 | 1 | _ | |a Halbach, Sebastian |b 9 |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 10 |
| 700 | 1 | _ | |a Northcott, Paul A |b 11 |
| 700 | 1 | _ | |a Sturm, Dominik |0 0000-0003-0250-1696 |b 12 |
| 700 | 1 | _ | |a Bjerke, Lynn |b 13 |
| 700 | 1 | _ | |a Zichner, Thomas |0 0000-0001-9848-7598 |b 14 |
| 700 | 1 | _ | |a Stütz, Adrian M |b 15 |
| 700 | 1 | _ | |a Schramm, Kathrin |b 16 |
| 700 | 1 | _ | |a Huang, Bingding |b 17 |
| 700 | 1 | _ | |a Buchhalter, Ivo |0 0000-0003-0764-5832 |b 18 |
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| 700 | 1 | _ | |a Weber, Ursula D |b 23 |
| 700 | 1 | _ | |a Zapatka, Marc |0 0000-0001-8287-5967 |b 24 |
| 700 | 1 | _ | |a Raeder, Benjamin |b 25 |
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| 700 | 1 | _ | |a Sehested, Astrid M |b 39 |
| 700 | 1 | _ | |a Sumerauer, David |b 40 |
| 700 | 1 | _ | |a Brahim, Dorra Hmida-Ben |b 41 |
| 700 | 1 | _ | |a Trabelsi, Saoussen |b 42 |
| 700 | 1 | _ | |a Ng, Ho-Keung |b 43 |
| 700 | 1 | _ | |a Zagzag, David |b 44 |
| 700 | 1 | _ | |a Allen, Jeffrey C |b 45 |
| 700 | 1 | _ | |a Karajannis, Matthias A |0 0000-0002-7151-6528 |b 46 |
| 700 | 1 | _ | |a Gottardo, Nicholas G |b 47 |
| 700 | 1 | _ | |a Jones, Chris |b 48 |
| 700 | 1 | _ | |a Korbel, Jan O |0 0000-0002-2798-3794 |b 49 |
| 700 | 1 | _ | |a Schmidt, Sabine |0 P:(DE-He78)d6e2a991c1003a27b302b66a5477e6cd |b 50 |
| 700 | 1 | _ | |a Wolf, Stephan |0 P:(DE-He78)1efb774993effe7a66a6ffc1b1cf9ccb |b 51 |
| 700 | 1 | _ | |a Reifenberger, Guido |b 52 |
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| 700 | 1 | _ | |a Brors, Benedikt |0 P:(DE-He78)fc949170377b58098e46141d95c72661 |b 54 |
| 700 | 1 | _ | |a Herold-Mende, Christel |b 55 |
| 700 | 1 | _ | |a Lehrach, Hans |b 56 |
| 700 | 1 | _ | |a Brummer, Tilman |b 57 |
| 700 | 1 | _ | |a Korshunov, Andrey |b 58 |
| 700 | 1 | _ | |a Eils, Roland |0 P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0 |b 59 |
| 700 | 1 | _ | |a Yaspo, Marie-Laure |0 0000-0002-9555-9979 |b 60 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 61 |e Last author |
| 700 | 1 | _ | |a Lichter, Peter |0 P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c |b 62 |e Last author |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 63 |e Last author |
| 700 | 1 | _ | |a , , International Cancer Genome Consortium PedBrain Tumor Project. |0 P:(DE-HGF)0 |b 64 |e Collaboration author |
| 773 | _ | _ | |a 10.1038/nm.4204 |g Vol. 22, no. 11, p. 1314 - 1320 |0 PERI:(DE-600)1484517-9 |n 11 |p 1314 - 1320 |t Nature medicine |v 22 |y 2016 |x 1546-170X |
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