Home > Publications database > NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice. > print

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024 7 _ |a 10.1002/eji.201545925
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024 7 _ |a 0014-2980
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024 7 _ |a 1521-4141
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037 _ _ |a DKFZ-2017-01719
041 _ _ |a eng
082 _ _ |a 610
100 1 _ |a Busch, Rhoda
|b 0
245 _ _ |a NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.
260 _ _ |a Weinheim
|c 2016
|b Wiley-VCH
336 7 _ |a article
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336 7 _ |a Journal Article
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520 _ _ |a The link between the extensive usage of calcineurin (CN) inhibitors cyclosporin A and tacrolimus (FK506) in transplantation medicine and the increasing rate of opportunistic infections within this segment of patients is alarming. Currently, how peritoneal infections are favored by these drugs, which impair the activity of several signaling pathways including the Ca(++) /CN/NFAT, Ca(++) /CN/cofilin, Ca(++) /CN/BAD, and NF-κB networks, is unknown. Here, we show that Saccharomyces cerevisiae infection of peritoneal resident macrophages triggers the transient nuclear translocation of NFATc1β isoforms, resulting in a coordinated, CN-dependent induction of the Ccl2, Ccl7, and Ccl12 genes, all encoding CCR2 agonists. CN inhibitors block the CCR2-dependent recruitment of inflammatory monocytes (IM) to the peritoneal cavities of S. cerevisiae infected mice. In myeloid cells, NFATc1/β proteins represent the most prominent NFATc1 isoforms. NFATc1/β ablation leads to a decrease of CCR2 chemokines, impaired mobilization of IMs, and delayed clearance of infection. We show that, upon binding to a composite NFAT/BCL6 regulatory element within the Ccl2 promoter, NFATc1/β proteins release the BCL6-dependent repression of Ccl2 gene in macrophages. These findings suggest a novel CN-dependent cross-talk between NFAT and BCL6 transcription factors, which may affect the outcome of opportunistic fungal infections in immunocompromised patients.
536 _ _ |a 314 - Tumor immunology (POF3-314)
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650 _ 7 |a Calcineurin Inhibitors
|2 NLM Chemicals
650 _ 7 |a Ccl12 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Ccl2 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Ccl7 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Ccr2 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Chemokine CCL2
|2 NLM Chemicals
650 _ 7 |a Chemokine CCL7
|2 NLM Chemicals
650 _ 7 |a Monocyte Chemoattractant Proteins
|2 NLM Chemicals
650 _ 7 |a NF-kappa B
|2 NLM Chemicals
650 _ 7 |a NFATC Transcription Factors
|2 NLM Chemicals
650 _ 7 |a Nfatc1 protein, mouse
|2 NLM Chemicals
650 _ 7 |a Protein Isoforms
|2 NLM Chemicals
650 _ 7 |a Proto-Oncogene Proteins c-bcl-6
|2 NLM Chemicals
650 _ 7 |a Receptors, CCR2
|2 NLM Chemicals
650 _ 7 |a Calcineurin
|0 EC 3.1.3.16
|2 NLM Chemicals
700 1 _ |a Murti, Krisna
|b 1
700 1 _ |a Liu, Jiming
|b 2
700 1 _ |a Patra, Amiya K
|b 3
700 1 _ |a Muhammad, Khalid
|b 4
700 1 _ |a Knobeloch, Klaus-Peter
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700 1 _ |a Lichtinger, Monika
|b 6
700 1 _ |a Bonifer, Constanze
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700 1 _ |a Wörtge, Simone
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700 1 _ |a Waisman, Ari
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700 1 _ |a Reifenberg, Kurt
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700 1 _ |a Ellenrieder, Volker
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700 1 _ |a Serfling, Edgar
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700 1 _ |a Avots, Andris
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773 _ _ |a 10.1002/eji.201545925
|g Vol. 46, no. 3, p. 634 - 646
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|t European journal of immunology
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910 1 _ |a Deutsches Krebsforschungszentrum
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