TY  - JOUR
AU  - Carceller, Fernando
AU  - Fowkes, Lucy A
AU  - Khabra, Komel
AU  - Moreno, Lucas
AU  - Saran, Frank
AU  - Burford, Anna
AU  - Mackay, Alan
AU  - Jones, David
AU  - Hovestadt, Volker
AU  - Marshall, Lynley V
AU  - Vaidya, Sucheta
AU  - Mandeville, Henry
AU  - Jerome, Neil
AU  - Bridges, Leslie R
AU  - Laxton, Ross
AU  - Al-Sarraj, Safa
AU  - Pfister, Stefan
AU  - Leach, Martin O
AU  - Pearson, Andrew D J
AU  - Jones, Chris
AU  - Koh, Dow-Mu
AU  - Zacharoulis, Stergios
TI  - Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma.
JO  - Journal of neuro-oncology
VL  - 129
IS  - 1
SN  - 1573-7373
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DKFZ-2017-01733
SP  - 109 - 121
PY  - 2016
AB  - Pseudoprogression (PsP) is a treatment-related phenomenon which hinders response interpretation. Its prevalence and clinical impact have not been evaluated in children/adolescents. We assessed the characteristics, risk factors and prognosis of PsP in children/adolescents and young-adults diagnosed with non-brainstem high grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG). Patients aged 1-21 years diagnosed with HGG or DIPG between 1995 and 2012 who had completed radiotherapy were eligible. PsP was assessed according to study-specific criteria and correlated with first-line treatment, molecular biomarkers and survival. Ninety-one patients (47 HGG, 44 DIPG) were evaluable. Median age: 10 years (range, 2-20). Eleven episodes of PsP were observed in 10 patients (4 HGG, 6 DIPG). Rates of PsP: 8.5 
LB  - PUB:(DE-HGF)16
C6  - pmid:27180091
DO  - DOI:10.1007/s11060-016-2151-8
UR  - https://inrepo02.dkfz.de/record/125607
ER  -