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| Home > Publications database > Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma. > print |
| 001 | 125607 | ||
| 005 | 20240228143319.0 | ||
| 024 | 7 | _ | |a 10.1007/s11060-016-2151-8 |2 doi |
| 024 | 7 | _ | |a pmid:27180091 |2 pmid |
| 024 | 7 | _ | |a 0167-594X |2 ISSN |
| 024 | 7 | _ | |a 0167-594x |2 ISSN |
| 024 | 7 | _ | |a 1573-7373 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-01733 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Carceller, Fernando |b 0 |
| 245 | _ | _ | |a Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma. |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2016 |b Springer Science + Business Media B.V |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521723036_2109 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Pseudoprogression (PsP) is a treatment-related phenomenon which hinders response interpretation. Its prevalence and clinical impact have not been evaluated in children/adolescents. We assessed the characteristics, risk factors and prognosis of PsP in children/adolescents and young-adults diagnosed with non-brainstem high grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG). Patients aged 1-21 years diagnosed with HGG or DIPG between 1995 and 2012 who had completed radiotherapy were eligible. PsP was assessed according to study-specific criteria and correlated with first-line treatment, molecular biomarkers and survival. Ninety-one patients (47 HGG, 44 DIPG) were evaluable. Median age: 10 years (range, 2-20). Eleven episodes of PsP were observed in 10 patients (4 HGG, 6 DIPG). Rates of PsP: 8.5 % (HGG); 13.6 % (DIPG). Two episodes of PsP were based on clinical findings alone; nine episodes had concurrent radiological changes: increased size of lesions (n = 5), new focal enhancement (n = 4). Temozolomide, MGMT methylation or H3F3A mutations were not found to be associated with increased occurrence of PsP. For HGG, 1-year progression-free survival (PFS) was 41.9 % no-PsP versus 100 % PsP (p = 0.041); differences in 1-year overall survival (OS) were not significant. For DIPG, differences in 1-year PFS and OS were not statistically significant. Hazard ratio (95 %CI) of PsP for OS was 0.551 (0.168-1.803; p = 0.325) in HGG; and 0.308 (0.107-0.882; p = 0.028) in DIPG. PsP occurred in both pediatric HGG and DIPG patients at a comparable rate to adult HGG. PsP was associated with improved 1-yr PFS in HGG patients. PsP had a protective effect upon OS in DIPG patients. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Fowkes, Lucy A |b 1 |
| 700 | 1 | _ | |a Khabra, Komel |b 2 |
| 700 | 1 | _ | |a Moreno, Lucas |b 3 |
| 700 | 1 | _ | |a Saran, Frank |b 4 |
| 700 | 1 | _ | |a Burford, Anna |b 5 |
| 700 | 1 | _ | |a Mackay, Alan |b 6 |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 7 |u dkfz |
| 700 | 1 | _ | |a Hovestadt, Volker |0 P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc |b 8 |u dkfz |
| 700 | 1 | _ | |a Marshall, Lynley V |b 9 |
| 700 | 1 | _ | |a Vaidya, Sucheta |b 10 |
| 700 | 1 | _ | |a Mandeville, Henry |b 11 |
| 700 | 1 | _ | |a Jerome, Neil |b 12 |
| 700 | 1 | _ | |a Bridges, Leslie R |b 13 |
| 700 | 1 | _ | |a Laxton, Ross |b 14 |
| 700 | 1 | _ | |a Al-Sarraj, Safa |b 15 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 16 |u dkfz |
| 700 | 1 | _ | |a Leach, Martin O |b 17 |
| 700 | 1 | _ | |a Pearson, Andrew D J |b 18 |
| 700 | 1 | _ | |a Jones, Chris |b 19 |
| 700 | 1 | _ | |a Koh, Dow-Mu |b 20 |
| 700 | 1 | _ | |a Zacharoulis, Stergios |b 21 |
| 773 | _ | _ | |a 10.1007/s11060-016-2151-8 |g Vol. 129, no. 1, p. 109 - 121 |0 PERI:(DE-600)2007293-4 |n 1 |p 109 - 121 |t Journal of neuro-oncology |v 129 |y 2016 |x 1573-7373 |
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