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| Home > Publications database > Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice. > print |
| 001 | 125631 | ||
| 005 | 20240228143320.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pone.0157311 |2 doi |
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| 024 | 7 | _ | |a altmetric:10862329 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-01757 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Cheng, Fei |b 0 |
| 245 | _ | _ | |a Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice. |
| 260 | _ | _ | |a Lawrence, Kan. |c 2016 |b PLoS |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521118001_29643 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a This study focused on the unique properties of both the Ldlr knockout defect (closely mimicking the human situation) and the BALB/c (C) inbred mouse strain (Th-2 slanted immune response). We generated two immunodeficient strains with severe combined B- and T-cell immunodeficiency with or without a complete lack of natural killer cells to revisit the role of adaptive immune responses on atherogenesis. C-Ldlr-/- Rag1-/- mice, which show severe combined B- and T-cell immunodeficiency and C-Ldlr-/- Rag1-/- Il2rg-/- mice, which combine the T- and B-cell defect with a complete lack of natural killer cells and inactivation of multiple cytokine signalling pathways were fed an atherogenic Western type diet (WTD). Both B6-Ldlr-/- and C-Ldlr-/- immunocompetent mice were used as controls. Body weights and serum cholesterol levels of both immunodeficient strains were significantly increased compared to C-Ldlr-/- controls, except for cholesterol levels of C-Ldlr-/- Rag1-/- double mutants after 12 weeks on the WTD. Quantification of the aortic sinus plaque area revealed that both strains of immunodeficient mice developed significantly more atherosclerosis compared to C-Ldlr-/- controls after 24 weeks on the WTD. Increased atherosclerotic lesion development in C-Ldlr-/- Rag1-/- Il2rg-/- triple mutants was associated with significantly increased numbers of macrophages and significantly decreased numbers of smooth muscle cells compared to both C-Ldlr-/- wild type and C-Ldlr-/- Rag1-/- double mutants pointing to a plaque destabilizing effect of NK cell loss. Collectively, the present study reveals a previously unappreciated complexity with regard to the impact of lymphocytes on lipoprotein metabolism and the role of lymphocyte subsets in plaque composition. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Lipoproteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, LDL |2 NLM Chemicals |
| 650 | _ | 7 | |a Triglycerides |2 NLM Chemicals |
| 650 | _ | 7 | |a Cholesterol |0 97C5T2UQ7J |2 NLM Chemicals |
| 700 | 1 | _ | |a Twardowski, Laura |b 1 |
| 700 | 1 | _ | |a Reifenberg, Kurt |0 P:(DE-He78)ea7e63442b7f00c9561f7b959e237065 |b 2 |u dkfz |
| 700 | 1 | _ | |a Winter, Kerstin |b 3 |
| 700 | 1 | _ | |a Canisius, Antje |b 4 |
| 700 | 1 | _ | |a Pross, Eva |b 5 |
| 700 | 1 | _ | |a Fan, Jianglin |b 6 |
| 700 | 1 | _ | |a Schmitt, Edgar |b 7 |
| 700 | 1 | _ | |a Shultz, Leonard D |b 8 |
| 700 | 1 | _ | |a Lackner, Karl J |b 9 |
| 700 | 1 | _ | |a Torzewski, Michael |b 10 |
| 773 | _ | _ | |a 10.1371/journal.pone.0157311 |g Vol. 11, no. 8, p. e0157311 - |0 PERI:(DE-600)2267670-3 |n 8 |p e0157311 - |t PLoS one |v 11 |y 2016 |x 1932-6203 |
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| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)ea7e63442b7f00c9561f7b959e237065 |
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