%0 Journal Article
%A Cieciera, Matthaeus
%A Kratochwil, Clemens
%A Moltz, Jan
%A Kauczor, Hans Ulrich
%A Holland-Letz, Tim
%A Choyke, Peter
%A Mier, Walter
%A Haberkorn, Uwe
%A Giesel, Frederik
%T Semi-automatic 3D-volumetry of liver metastases from neuroendocrine tumors to improve combination therapy with 177Lu-DOTATOC and 90Y-DOTATOC.
%J Diagnostic and interventional radiology
%V 22
%N 3
%@ 1305-3612
%C Ankara
%M DKFZ-2017-01772
%P 201 - 206
%D 2016
%X Patients with neuroendocrine tumors (NET) often present with disseminated liver metastases and can be treated with a number of different nuclides or nuclide combinations in peptide receptor radionuclide therapy (PRRT) depending on tumor load and lesion diameter. For quantification of disseminated liver lesions, semi-automatic lesion detection is helpful to determine tumor burden and tumor diameter in a time efficient manner. Here, we aimed to evaluate semi-automated measurement of total metastatic burden for therapy stratification.Nineteen patients with liver metastasized NET underwent contrast-enhanced 1.5 T MRI using gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid. Liver metastases (n=1537) were segmented using Fraunhofer MEVIS Software for three-dimensional (3D) segmentation. All lesions were stratified according to longest 3D diameter >20 mm or ≤20 mm and relative contribution to tumor load was used for therapy stratification.Mean count of lesions ≤20 mm was 67.5 and mean count of lesions >20 mm was 13.4. However, mean contribution to total tumor volume of lesions ≤20 mm was 24
%K 177Lu-octreotide, DOTA(0)-Tyr(3)- (NLM Chemicals)
%K 90Y-octreotide, DOTA-Tyr(3)- (NLM Chemicals)
%K Radiopharmaceuticals (NLM Chemicals)
%K gadolinium ethoxybenzyl DTPA (NLM Chemicals)
%K Gadolinium DTPA (NLM Chemicals)
%K Octreotide (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27015320
%2 pmc:PMC4859734
%R 10.5152/dir.2015.15304
%U https://inrepo02.dkfz.de/record/125646