TY  - JOUR
AU  - Cieciera, Matthaeus
AU  - Kratochwil, Clemens
AU  - Moltz, Jan
AU  - Kauczor, Hans Ulrich
AU  - Holland-Letz, Tim
AU  - Choyke, Peter
AU  - Mier, Walter
AU  - Haberkorn, Uwe
AU  - Giesel, Frederik
TI  - Semi-automatic 3D-volumetry of liver metastases from neuroendocrine tumors to improve combination therapy with 177Lu-DOTATOC and 90Y-DOTATOC.
JO  - Diagnostic and interventional radiology
VL  - 22
IS  - 3
SN  - 1305-3612
CY  - Ankara
M1  - DKFZ-2017-01772
SP  - 201 - 206
PY  - 2016
AB  - Patients with neuroendocrine tumors (NET) often present with disseminated liver metastases and can be treated with a number of different nuclides or nuclide combinations in peptide receptor radionuclide therapy (PRRT) depending on tumor load and lesion diameter. For quantification of disseminated liver lesions, semi-automatic lesion detection is helpful to determine tumor burden and tumor diameter in a time efficient manner. Here, we aimed to evaluate semi-automated measurement of total metastatic burden for therapy stratification.Nineteen patients with liver metastasized NET underwent contrast-enhanced 1.5 T MRI using gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid. Liver metastases (n=1537) were segmented using Fraunhofer MEVIS Software for three-dimensional (3D) segmentation. All lesions were stratified according to longest 3D diameter >20 mm or ≤20 mm and relative contribution to tumor load was used for therapy stratification.Mean count of lesions ≤20 mm was 67.5 and mean count of lesions >20 mm was 13.4. However, mean contribution to total tumor volume of lesions ≤20 mm was 24
KW  - 177Lu-octreotide, DOTA(0)-Tyr(3)- (NLM Chemicals)
KW  - 90Y-octreotide, DOTA-Tyr(3)- (NLM Chemicals)
KW  - Radiopharmaceuticals (NLM Chemicals)
KW  - gadolinium ethoxybenzyl DTPA (NLM Chemicals)
KW  - Gadolinium DTPA (NLM Chemicals)
KW  - Octreotide (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27015320
C2  - pmc:PMC4859734
DO  - DOI:10.5152/dir.2015.15304
UR  - https://inrepo02.dkfz.de/record/125646
ER  -