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| 024 | 7 | _ | |a 10.1080/2162402X.2015.1075692 |2 doi |
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| 037 | _ | _ | |a DKFZ-2017-01874 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Echterdiek, Fabian |b 0 |
| 245 | _ | _ | |a Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer. |
| 260 | _ | _ | |a Austin, Tex. |c 2016 |b Landes Bioscience |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1524222507_29388 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Microsatellite instability (MSI-H) is caused by DNA mismatch repair deficiency and occurs in 15% of colorectal cancers. MSI-H cancers generate highly immunogenic frameshift peptide (FSP) antigens, which elicit pronounced local immune responses. A subset of MSI-H colorectal cancers develops in frame of Lynch syndrome, which represents an ideal human model for studying the concept of immunoediting. Immunoediting describes how continuous anti-tumoral immune surveillance of the host eventually leads to the selection of tumor cells that escape immune cell recognition and destruction. Between 30 and 40% of Lynch syndrome-associated colorectal cancers display loss of HLA class I antigen expression as a result of Beta2-microglobulin (B2M) mutations. Whether B2M mutations result from immunoediting has been unknown. To address this question, we related B2M mutation status of Lynch syndrome-associated colorectal cancer specimens (n = 30) to CD3-positive, CD8-positive and FOXP3-positive T cell infiltration in both tumor and normal mucosa. No significant correlation between B2M mutations and immune cell infiltration was observed in tumor tissue. However, FOXP3-positive T cell infiltration was significantly lower in normal mucosa adjacent to B2M-mutant (mt) compared to B2M-wild type (wt) tumors (mean: 0.98% FOXP3-positive area/region of interest (ROI) in B2M-wt vs. 0.52% FOXP3-positive area/ROI in B2M-mt, p = 0.023). Our results suggest that in the absence of immune-suppressive regulatory T cells (Treg), the outgrowth of less immunogenic B2M-mt tumor cells is favored. This finding supports the immunoediting concept in human solid cancer development and indicates a critical role of the immune milieu in normal colonic mucosa for the course of disease. |
| 536 | _ | _ | |a 317 - Translational cancer research (POF3-317) |0 G:(DE-HGF)POF3-317 |c POF3-317 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Janikovits, Jonas |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Staffa, Laura |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Müller, Meike |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Lahrmann, Bernd |b 4 |
| 700 | 1 | _ | |a Frühschütz, Monika |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Hartog, Benjamin |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Nelius, Nina |0 P:(DE-He78)af4b1091bd23a160b527ee39101ed100 |b 7 |u dkfz |
| 700 | 1 | _ | |a Benner, Axel |0 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |b 8 |u dkfz |
| 700 | 1 | _ | |a Tariverdian, Mirjam |b 9 |
| 700 | 1 | _ | |a von Knebel Doeberitz, Magnus |0 P:(DE-He78)11747cd1dc061b9333c0e3a3ff31bf2f |b 10 |u dkfz |
| 700 | 1 | _ | |a Grabe, Niels |b 11 |
| 700 | 1 | _ | |a Kloor, Matthias |0 P:(DE-HGF)0 |b 12 |e Last author |
| 773 | _ | _ | |a 10.1080/2162402X.2015.1075692 |g Vol. 5, no. 2, p. e1075692 - |0 PERI:(DE-600)2645309-5 |n 2 |p e1075692 - |t OncoImmunology |v 5 |y 2016 |x 2162-402X |
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