TY  - JOUR
AU  - Ernst, Aurélie
AU  - Jones, David
AU  - Maass, Kendra
AU  - Rode, Agata
AU  - Deeg, Katharina
AU  - Jebaraj, Billy Michael Chelliah
AU  - Korshunov, Andrey
AU  - Hovestadt, Volker
AU  - Tainsky, Michael A
AU  - Pajtler, Kristian
AU  - Bender, Sebastian
AU  - Brabetz, Sebastian
AU  - Gröbner, Susanne
AU  - Kool, Marcel
AU  - Devens, Frauke
AU  - Edelmann, Jennifer
AU  - Zhang, Cindy
AU  - Castelo-Branco, Pedro
AU  - Tabori, Uri
AU  - Malkin, David
AU  - Rippe, Karsten
AU  - Stilgenbauer, Stephan
AU  - Pfister, Stefan
AU  - Zapatka, Marc
AU  - Lichter, Peter
TI  - Telomere dysfunction and chromothripsis.
JO  - International journal of cancer
VL  - 138
IS  - 12
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2017-01907
SP  - 2905 - 2914
PY  - 2016
AB  - Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to play a role in the initiation of this phenomenon, which occurs in a large number of tumor entities. Here, we show that telomere attrition can indeed lead to catastrophic genomic events, and that telomere patterns differ between cells analyzed before and after such genomic catastrophes. Telomere length and telomere stabilization mechanisms diverge between samples with and without chromothripsis in a given tumor subtype. Longitudinal analyses of the evolution of chromothriptic patterns identify either stable patterns between matched primary and relapsed tumors, or loss of the chromothriptic clone in the relapsed specimen. The absence of additional chromothriptic events occurring between the initial tumor and the relapsed tumor sample points to telomere stabilization after the initial chromothriptic event which prevents further shattering of the genome.
KW  - TERT protein, human (NLM Chemicals)
KW  - Telomerase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26856307
DO  - DOI:10.1002/ijc.30033
UR  - https://inrepo02.dkfz.de/record/125781
ER  -