% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ernst:125781,
      author       = {A. Ernst$^*$ and D. Jones$^*$ and K. Maass$^*$ and A.
                      Rode$^*$ and K. Deeg$^*$ and B. M. C. Jebaraj and A.
                      Korshunov$^*$ and V. Hovestadt$^*$ and M. A. Tainsky and K.
                      Pajtler$^*$ and S. Bender$^*$ and S. Brabetz$^*$ and S.
                      Gröbner$^*$ and M. Kool$^*$ and F. Devens$^*$ and J.
                      Edelmann and C. Zhang and P. Castelo-Branco and U. Tabori
                      and D. Malkin and K. Rippe$^*$ and S. Stilgenbauer and S.
                      Pfister$^*$ and M. Zapatka$^*$ and P. Lichter$^*$},
      title        = {{T}elomere dysfunction and chromothripsis.},
      journal      = {International journal of cancer},
      volume       = {138},
      number       = {12},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-01907},
      pages        = {2905 - 2914},
      year         = {2016},
      abstract     = {Chromothripsis is a recently discovered form of genomic
                      instability, characterized by tens to hundreds of clustered
                      DNA rearrangements resulting from a single dramatic event.
                      Telomere dysfunction has been suggested to play a role in
                      the initiation of this phenomenon, which occurs in a large
                      number of tumor entities. Here, we show that telomere
                      attrition can indeed lead to catastrophic genomic events,
                      and that telomere patterns differ between cells analyzed
                      before and after such genomic catastrophes. Telomere length
                      and telomere stabilization mechanisms diverge between
                      samples with and without chromothripsis in a given tumor
                      subtype. Longitudinal analyses of the evolution of
                      chromothriptic patterns identify either stable patterns
                      between matched primary and relapsed tumors, or loss of the
                      chromothriptic clone in the relapsed specimen. The absence
                      of additional chromothriptic events occurring between the
                      initial tumor and the relapsed tumor sample points to
                      telomere stabilization after the initial chromothriptic
                      event which prevents further shattering of the genome.},
      keywords     = {TERT protein, human (NLM Chemicals) / Telomerase (NLM
                      Chemicals)},
      cin          = {B060 / B062 / B066 / G380},
      ddc          = {610},
      cid          = {I:(DE-He78)B060-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)B066-20160331 / I:(DE-He78)G380-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26856307},
      doi          = {10.1002/ijc.30033},
      url          = {https://inrepo02.dkfz.de/record/125781},
}