guest ::
| Home > Publications database > Telomere dysfunction and chromothripsis. > print |
| 001 | 125781 | ||
| 005 | 20240228143331.0 | ||
| 024 | 7 | _ | |a 10.1002/ijc.30033 |2 doi |
| 024 | 7 | _ | |a pmid:26856307 |2 pmid |
| 024 | 7 | _ | |a 0020-7136 |2 ISSN |
| 024 | 7 | _ | |a 1097-0215 |2 ISSN |
| 024 | 7 | _ | |a altmetric:5112077 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-01907 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ernst, Aurélie |0 P:(DE-He78)509fb81813c1911954da583129e8ea57 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Telomere dysfunction and chromothripsis. |
| 260 | _ | _ | |a Bognor Regis |c 2016 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521724891_16575 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to play a role in the initiation of this phenomenon, which occurs in a large number of tumor entities. Here, we show that telomere attrition can indeed lead to catastrophic genomic events, and that telomere patterns differ between cells analyzed before and after such genomic catastrophes. Telomere length and telomere stabilization mechanisms diverge between samples with and without chromothripsis in a given tumor subtype. Longitudinal analyses of the evolution of chromothriptic patterns identify either stable patterns between matched primary and relapsed tumors, or loss of the chromothriptic clone in the relapsed specimen. The absence of additional chromothriptic events occurring between the initial tumor and the relapsed tumor sample points to telomere stabilization after the initial chromothriptic event which prevents further shattering of the genome. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a TERT protein, human |0 EC 2.7.7.49 |2 NLM Chemicals |
| 650 | _ | 7 | |a Telomerase |0 EC 2.7.7.49 |2 NLM Chemicals |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 1 |u dkfz |
| 700 | 1 | _ | |a Maass, Kendra |0 P:(DE-He78)5100059e746b377e2e0a37c0e24f6bf7 |b 2 |u dkfz |
| 700 | 1 | _ | |a Rode, Agata |0 P:(DE-He78)589c214eab93a46a3c170485420edfcb |b 3 |u dkfz |
| 700 | 1 | _ | |a Deeg, Katharina |0 P:(DE-He78)307c43dc6b7bbf6ca6c8a29fdeb01851 |b 4 |u dkfz |
| 700 | 1 | _ | |a Jebaraj, Billy Michael Chelliah |b 5 |
| 700 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 6 |u dkfz |
| 700 | 1 | _ | |a Hovestadt, Volker |0 P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc |b 7 |u dkfz |
| 700 | 1 | _ | |a Tainsky, Michael A |b 8 |
| 700 | 1 | _ | |a Pajtler, Kristian |0 P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d |b 9 |u dkfz |
| 700 | 1 | _ | |a Bender, Sebastian |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Brabetz, Sebastian |0 P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629 |b 11 |u dkfz |
| 700 | 1 | _ | |a Gröbner, Susanne |0 P:(DE-He78)932918ed0e8d8790a81235528019a8e0 |b 12 |u dkfz |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 13 |u dkfz |
| 700 | 1 | _ | |a Devens, Frauke |0 P:(DE-He78)83cd6bd6ea17b47e625c371d6415bdea |b 14 |u dkfz |
| 700 | 1 | _ | |a Edelmann, Jennifer |b 15 |
| 700 | 1 | _ | |a Zhang, Cindy |b 16 |
| 700 | 1 | _ | |a Castelo-Branco, Pedro |b 17 |
| 700 | 1 | _ | |a Tabori, Uri |b 18 |
| 700 | 1 | _ | |a Malkin, David |b 19 |
| 700 | 1 | _ | |a Rippe, Karsten |0 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |b 20 |u dkfz |
| 700 | 1 | _ | |a Stilgenbauer, Stephan |b 21 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 22 |u dkfz |
| 700 | 1 | _ | |a Zapatka, Marc |0 P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7 |b 23 |u dkfz |
| 700 | 1 | _ | |a Lichter, Peter |0 P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c |b 24 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/ijc.30033 |g Vol. 138, no. 12, p. 2905 - 2914 |0 PERI:(DE-600)1474822-8 |n 12 |p 2905 - 2914 |t International journal of cancer |v 138 |y 2016 |x 0020-7136 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:125781 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)509fb81813c1911954da583129e8ea57 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)551bb92841f634070997aa168d818492 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)5100059e746b377e2e0a37c0e24f6bf7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)589c214eab93a46a3c170485420edfcb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)307c43dc6b7bbf6ca6c8a29fdeb01851 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 10 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 11 |6 P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 12 |6 P:(DE-He78)932918ed0e8d8790a81235528019a8e0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 13 |6 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)83cd6bd6ea17b47e625c371d6415bdea |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 20 |6 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 22 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 23 |6 P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 24 |6 P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2016 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b INT J CANCER : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b INT J CANCER : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)B060-20160331 |k B060 |l Molekulare Genetik |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)B066-20160331 |k B066 |l Genomorganisation und Funktion |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)G380-20160331 |k G380 |l KKE Neuropathologie |x 3 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B060-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B066-20160331 |
| 980 | _ | _ | |a I:(DE-He78)G380-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|