%0 Journal Article %A Fellenberg, Jörg %A Sähr, Heiner %A Kunz, Pierre %A Zhao, Zhefu %A Liu, Li %A Tichy, Diana %A Herr, Ingrid %T Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. %J Cancer letters %V 371 %N 1 %@ 0304-3835 %C Amsterdam [u.a.] %I Elsevier Science %M DKFZ-2017-01935 %P 134 - 141 %D 2016 %X Although generally benign, giant cell tumors of bone (GCTB) display an aggressive behavior associated with significant bone destruction and lung metastasis in rare cases. This and the very high recurrence rate observed after surgical resection ranging from 20 to 55 %K Gle1 protein, human (NLM Chemicals) %K MIRN127 microRNA, human (NLM Chemicals) %K MIRN376 microRNA, human (NLM Chemicals) %K MicroRNAs (NLM Chemicals) %K Nucleocytoplasmic Transport Proteins (NLM Chemicals) %K PDIA6 protein, human (NLM Chemicals) %K Protein Disulfide-Isomerases (NLM Chemicals) %F PUB:(DE-HGF)16 %9 Journal Article %$ pmid:26655997 %R 10.1016/j.canlet.2015.10.039 %U https://inrepo02.dkfz.de/record/125811