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000125813 0247_ $$2ISSN$$a0340-5761
000125813 0247_ $$2ISSN$$a1432-0738
000125813 037__ $$aDKFZ-2017-01937
000125813 041__ $$aeng
000125813 082__ $$a610
000125813 1001_ $$aFernando, Ruani N$$b0
000125813 245__ $$a'Watching the Detectives' report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.
000125813 260__ $$aBerlin$$bSpringer$$c2016
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000125813 520__ $$aSEURAT-1 is a joint research initiative between the European Commission and Cosmetics Europe aiming to develop in vitro- and in silico-based methods to replace the in vivo repeated dose systemic toxicity test used for the assessment of human safety. As one of the building blocks of SEURAT-1, the DETECTIVE project focused on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically acting toxicants, relevant for humans. The work conducted by the DETECTIVE consortium partners has established a screening pipeline of functional and '-omics' technologies, including high-content and high-throughput screening platforms, to develop and investigate human biomarkers for repeated dose toxicity in cellular in vitro models. Identification and statistical selection of highly predictive biomarkers in a pathway- and evidence-based approach constitute a major step in an integrated approach towards the replacement of animal testing in human safety assessment. To discuss the final outcomes and achievements of the consortium, a meeting was organized in Brussels. This meeting brought together data-producing and supporting consortium partners. The presentations focused on the current state of ongoing and concluding projects and the strategies employed to identify new relevant biomarkers of toxicity. The outcomes and deliverables, including the dissemination of results in data-rich '-omics' databases, were discussed as were the future perspectives of the work completed under the DETECTIVE project. Although some projects were still in progress and required continued data analysis, this report summarizes the presentations, discussions and the outcomes of the project.
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000125813 7001_ $$aChaudhari, Umesh$$b1
000125813 7001_ $$aEscher, Sylvia E$$b2
000125813 7001_ $$aHengstler, Jan G$$b3
000125813 7001_ $$aHescheler, Jürgen$$b4
000125813 7001_ $$aJennings, Paul$$b5
000125813 7001_ $$aKeun, Hector C$$b6
000125813 7001_ $$aKleinjans, Jos C S$$b7
000125813 7001_ $$aKolde, Raivo$$b8
000125813 7001_ $$aKollipara, Laxmikanth$$b9
000125813 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b10$$udkfz
000125813 7001_ $$aLimonciel, Alice$$b11
000125813 7001_ $$aNemade, Harshal$$b12
000125813 7001_ $$aNguemo, Filomain$$b13
000125813 7001_ $$aPeterson, Hedi$$b14
000125813 7001_ $$aPrieto, Pilar$$b15
000125813 7001_ $$aRodrigues, Robim M$$b16
000125813 7001_ $$aSachinidis, Agapios$$b17
000125813 7001_ $$aSchäfer, Christoph$$b18
000125813 7001_ $$aSickmann, Albert$$b19
000125813 7001_ $$aSpitkovsky, Dimitry$$b20
000125813 7001_ $$aStöber, Regina$$b21
000125813 7001_ $$avan Breda, Simone G J$$b22
000125813 7001_ $$avan de Water, Bob$$b23
000125813 7001_ $$aVivier, Manon$$b24
000125813 7001_ $$aZahedi, René P$$b25
000125813 7001_ $$aVinken, Mathieu$$b26
000125813 7001_ $$aRogiers, Vera$$b27
000125813 773__ $$0PERI:(DE-600)1458459-1$$a10.1007/s00204-016-1719-6$$gVol. 90, no. 6, p. 1529 - 1539$$n6$$p1529 - 1539$$tArchives of toxicology$$v90$$x1432-0738$$y2016
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