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@ARTICLE{Fernando:125813,
      author       = {R. N. Fernando and U. Chaudhari and S. E. Escher and J. G.
                      Hengstler and J. Hescheler and P. Jennings and H. C. Keun
                      and J. C. S. Kleinjans and R. Kolde and L. Kollipara and A.
                      Kopp-Schneider$^*$ and A. Limonciel and H. Nemade and F.
                      Nguemo and H. Peterson and P. Prieto and R. M. Rodrigues and
                      A. Sachinidis and C. Schäfer and A. Sickmann and D.
                      Spitkovsky and R. Stöber and S. G. J. van Breda and B. van
                      de Water and M. Vivier and R. P. Zahedi and M. Vinken and V.
                      Rogiers},
      title        = {'{W}atching the {D}etectives' report of the general
                      assembly of the {EU} project {DETECTIVE} {B}russels, 24-25
                      {N}ovember 2015.},
      journal      = {Archives of toxicology},
      volume       = {90},
      number       = {6},
      issn         = {1432-0738},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-01937},
      pages        = {1529 - 1539},
      year         = {2016},
      abstract     = {SEURAT-1 is a joint research initiative between the
                      European Commission and Cosmetics Europe aiming to develop
                      in vitro- and in silico-based methods to replace the in vivo
                      repeated dose systemic toxicity test used for the assessment
                      of human safety. As one of the building blocks of SEURAT-1,
                      the DETECTIVE project focused on a key element on which in
                      vitro toxicity testing relies: the development of robust and
                      reliable, sensitive and specific in vitro biomarkers and
                      surrogate endpoints that can be used for safety assessments
                      of chronically acting toxicants, relevant for humans. The
                      work conducted by the DETECTIVE consortium partners has
                      established a screening pipeline of functional and '-omics'
                      technologies, including high-content and high-throughput
                      screening platforms, to develop and investigate human
                      biomarkers for repeated dose toxicity in cellular in vitro
                      models. Identification and statistical selection of highly
                      predictive biomarkers in a pathway- and evidence-based
                      approach constitute a major step in an integrated approach
                      towards the replacement of animal testing in human safety
                      assessment. To discuss the final outcomes and achievements
                      of the consortium, a meeting was organized in Brussels. This
                      meeting brought together data-producing and supporting
                      consortium partners. The presentations focused on the
                      current state of ongoing and concluding projects and the
                      strategies employed to identify new relevant biomarkers of
                      toxicity. The outcomes and deliverables, including the
                      dissemination of results in data-rich '-omics' databases,
                      were discussed as were the future perspectives of the work
                      completed under the DETECTIVE project. Although some
                      projects were still in progress and required continued data
                      analysis, this report summarizes the presentations,
                      discussions and the outcomes of the project.},
      keywords     = {Biomarkers (NLM Chemicals)},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27129694},
      pmc          = {pmc:PMC5435100},
      doi          = {10.1007/s00204-016-1719-6},
      url          = {https://inrepo02.dkfz.de/record/125813},
}