000125825 001__ 125825
000125825 005__ 20240228140801.0
000125825 0247_ $$2doi$$a10.5152/dir.2015.15220
000125825 0247_ $$2pmid$$apmid:26611258
000125825 0247_ $$2pmc$$apmc:PMC4712895
000125825 0247_ $$2ISSN$$a1305-3612
000125825 0247_ $$2ISSN$$a1305-3825
000125825 037__ $$aDKFZ-2017-01949
000125825 041__ $$aeng
000125825 082__ $$a610
000125825 1001_ $$aFlechsig, Paul$$b0
000125825 245__ $$aIncreased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer.
000125825 260__ $$aAnkara$$c2015
000125825 3367_ $$2DRIVER$$aarticle
000125825 3367_ $$2DataCite$$aOutput Types/Journal article
000125825 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1524741254_17079
000125825 3367_ $$2BibTeX$$aARTICLE
000125825 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000125825 3367_ $$00$$2EndNote$$aJournal Article
000125825 520__ $$aStaging of lung cancer is typically performed with fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET/CT); however, false positive PET scans can occur due to inflammatory disease. The CT scan is used for anatomic registration and attenuation correction. Herein, we evaluated x-ray attenuation (XRA) within nodes on CT and correlated this with the presence of malignancy in an orthotopic lung cancer model in rats.1×10⁶ NCI-H460 cells were injected transthoracically in six National Institutes of Health nude rats and six animals served as controls. After two weeks, animals were sacrificed; lymph nodes were extracted and scanned with a micro-CT to determine their XRA prior to histologic analysis.Median CT density in malignant lymph nodes (n=20) was significantly higher than benign lymph nodes (n=12; P = 0.018). Short-axis diameter of metastatic lymph nodes was significantly different than benign nodes (3.4 mm vs. 2.4 mm; P = 0.025). Area under the curve for malignancy was higher for density-based lymph node analysis compared with size measurements (0.87 vs. 0.7).XRA of metastatic mediastinal lymph nodes is significantly higher than benign nodes in this lung cancer model. This suggests that information on nodal density may be useful when used in combination with the results of FDG-PET in determining the likelihood of malignant adenopathy.
000125825 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000125825 588__ $$aDataset connected to CrossRef, PubMed,
000125825 650_7 $$2NLM Chemicals$$aRadiopharmaceuticals
000125825 650_7 $$00Z5B2CJX4D$$2NLM Chemicals$$aFluorodeoxyglucose F18
000125825 7001_ $$aChoyke, Peter$$b1
000125825 7001_ $$aKratochwil, Clemens$$b2
000125825 7001_ $$aWarth, Arne$$b3
000125825 7001_ $$aAntoch, Gerald$$b4
000125825 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b5$$udkfz
000125825 7001_ $$aRath, Daniel$$b6
000125825 7001_ $$0P:(DE-He78)1062e10961e437a74b9dd7542cd4ba7c$$aEichwald, Viktoria$$b7$$udkfz
000125825 7001_ $$0P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aHuber, Peter$$b8$$udkfz
000125825 7001_ $$aKauczor, Hans-Ulrich$$b9
000125825 7001_ $$0P:(DE-He78)13a0afba029f5f64dc18b25ef7499558$$aHaberkorn, Uwe$$b10$$udkfz
000125825 7001_ $$0P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94$$aGiesel, Frederik$$b11$$eLast author$$udkfz
000125825 773__ $$0PERI:(DE-600)2184145-7$$a10.5152/dir.2015.15220$$gVol. 22, no. 1, p. 35 - 39$$n1$$p35 - 39$$tDiagnostic and interventional radiology$$v22$$x1305-3612$$y2015
000125825 909CO $$ooai:inrepo02.dkfz.de:125825$$pVDB
000125825 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000125825 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)1062e10961e437a74b9dd7542cd4ba7c$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000125825 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000125825 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)13a0afba029f5f64dc18b25ef7499558$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000125825 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000125825 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000125825 9141_ $$y2015
000125825 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000125825 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000125825 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bDIAGN INTERV RADIOL : 2015
000125825 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000125825 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000125825 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000125825 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000125825 9201_ $$0I:(DE-He78)C060-20160331$$kC060$$lBiostatistik$$x0
000125825 9201_ $$0I:(DE-He78)W240-20160331$$kW240$$lKleintierbildgebung$$x1
000125825 9201_ $$0I:(DE-He78)E055-20160331$$kE055$$lMolekulare Radioonkologie$$x2
000125825 9201_ $$0I:(DE-He78)E060-20160331$$kE060$$lKKE Nuklearmedizin$$x3
000125825 980__ $$ajournal
000125825 980__ $$aVDB
000125825 980__ $$aI:(DE-He78)C060-20160331
000125825 980__ $$aI:(DE-He78)W240-20160331
000125825 980__ $$aI:(DE-He78)E055-20160331
000125825 980__ $$aI:(DE-He78)E060-20160331
000125825 980__ $$aUNRESTRICTED