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@ARTICLE{Flechsig:125825,
      author       = {P. Flechsig and P. Choyke and C. Kratochwil and A. Warth
                      and G. Antoch and T. Holland-Letz$^*$ and D. Rath and V.
                      Eichwald$^*$ and P. Huber$^*$ and H.-U. Kauczor and U.
                      Haberkorn$^*$ and F. Giesel$^*$},
      title        = {{I}ncreased x-ray attenuation in malignant vs. benign
                      mediastinal nodes in an orthotopic model of lung cancer.},
      journal      = {Diagnostic and interventional radiology},
      volume       = {22},
      number       = {1},
      issn         = {1305-3612},
      address      = {Ankara},
      reportid     = {DKFZ-2017-01949},
      pages        = {35 - 39},
      year         = {2015},
      abstract     = {Staging of lung cancer is typically performed with
                      fluorodeoxyglucose-positron emission tomography-computed
                      tomography (FDG-PET/CT); however, false positive PET scans
                      can occur due to inflammatory disease. The CT scan is used
                      for anatomic registration and attenuation correction.
                      Herein, we evaluated x-ray attenuation (XRA) within nodes on
                      CT and correlated this with the presence of malignancy in an
                      orthotopic lung cancer model in rats.1×10⁶ NCI-H460 cells
                      were injected transthoracically in six National Institutes
                      of Health nude rats and six animals served as controls.
                      After two weeks, animals were sacrificed; lymph nodes were
                      extracted and scanned with a micro-CT to determine their XRA
                      prior to histologic analysis.Median CT density in malignant
                      lymph nodes (n=20) was significantly higher than benign
                      lymph nodes (n=12; P = 0.018). Short-axis diameter of
                      metastatic lymph nodes was significantly different than
                      benign nodes (3.4 mm vs. 2.4 mm; P = 0.025). Area under the
                      curve for malignancy was higher for density-based lymph node
                      analysis compared with size measurements (0.87 vs. 0.7).XRA
                      of metastatic mediastinal lymph nodes is significantly
                      higher than benign nodes in this lung cancer model. This
                      suggests that information on nodal density may be useful
                      when used in combination with the results of FDG-PET in
                      determining the likelihood of malignant adenopathy.},
      keywords     = {Radiopharmaceuticals (NLM Chemicals) / Fluorodeoxyglucose
                      F18 (NLM Chemicals)},
      cin          = {C060 / W240 / E055 / E060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)W240-20160331 /
                      I:(DE-He78)E055-20160331 / I:(DE-He78)E060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26611258},
      pmc          = {pmc:PMC4712895},
      doi          = {10.5152/dir.2015.15220},
      url          = {https://inrepo02.dkfz.de/record/125825},
}