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@ARTICLE{Florath:125827,
      author       = {I. Florath$^*$ and B. Schöttker$^*$ and K. Butterbach$^*$
                      and M. Bewerunge-Hudler$^*$ and H. Brenner$^*$},
      title        = {{E}pigenome-wide search for association of serum
                      25-hydroxyvitamin {D} concentration with leukocyte {DNA}
                      methylation in a large cohort of older men.},
      journal      = {Epigenomics},
      volume       = {8},
      number       = {4},
      issn         = {1750-192X},
      address      = {London},
      publisher    = {Future Medicine Ltd.},
      reportid     = {DKFZ-2017-01951},
      pages        = {487 - 499},
      year         = {2016},
      abstract     = {We aimed for an epigenome-wide identification of vitamin
                      D-associated CpG sites in leukocyte DNA.Infinium
                      HumanMethylation450BeadChip measurements in 402 Caucasian
                      older men were evaluated for significant association with
                      25-hydroxy-vitamin (25(OH)D) using Spearman's correlation
                      and median regression to adjust for confounding variables. A
                      cross-validation approach as well as a bootstrapping
                      procedure were implemented to determine the replicability of
                      significant associations. Multiple testing was corrected for
                      by Benjamini-Hochberg or Bonferroni.Although in the
                      screening subcohorts significant associations of DNAm with
                      25(OH)D were observed in the validation cohorts these
                      associations were not replicated after adjustment for
                      potential confounders. At none of the 361,945 CpGs a
                      significant association of DNAm with 25(OH)D was found in
                      all 100 random bootstrap samples, but in comparison at 462
                      CpGs for the well-established association with age.Leukocyte
                      DNAm was not associated with 25(OH)D levels after validation
                      and consideration of confounders.},
      keywords     = {Vitamin D (NLM Chemicals) / 25-hydroxyvitamin D (NLM
                      Chemicals)},
      cin          = {C070 / W110 / L101},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)W110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27035505},
      doi          = {10.2217/epi.16.4},
      url          = {https://inrepo02.dkfz.de/record/125827},
}