TY  - JOUR
AU  - Florath, Ines
AU  - Butterbach, Katja
AU  - Heiss, Jonathan
AU  - Bewerunge-Hudler, Melanie
AU  - Zhang, Yan
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults.
JO  - Diabetologia
VL  - 59
IS  - 1
SN  - 1432-0428
CY  - Berlin
PB  - Springer
M1  - DKFZ-2017-01952
SP  - 130 - 138
PY  - 2016
AB  - Development of type 2 diabetes depends on environmental and genetic factors. We investigated the epigenome-wide association of prevalent diabetes with DNA methylation (DNAm) in peripheral blood.DNAm was measured in whole blood with the Illumina Infinium HumanMethylation450 BeadChip in two subsamples of participants from the ESTHER cohort study. Cohort 1 included 988 participants, who were consecutively recruited between July and October 2000 and cohort 2 included 527 randomly selected participants. The association of DNAm with prevalent type 2 diabetes at recruitment was estimated using median regression analysis adjusting for sex, age, BMI, smoking behaviour, cell composition and batch at 361,922 CpG sites.Type 2 diabetes was prevalent in 16
KW  - 3' Untranslated Regions (NLM Chemicals)
KW  - Blood Glucose (NLM Chemicals)
KW  - Carrier Proteins (NLM Chemicals)
KW  - TXNIP protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26433941
DO  - DOI:10.1007/s00125-015-3773-7
UR  - https://inrepo02.dkfz.de/record/125828
ER  -