TY  - JOUR
AU  - Giesel, Frederik
AU  - Sterzing, F.
AU  - Schlemmer, H. P.
AU  - Holland-Letz, T.
AU  - Mier, W.
AU  - Rius, M.
AU  - Afshar-Oromieh, A.
AU  - Kopka, K.
AU  - Debus, J.
AU  - Haberkorn, U.
AU  - Kratochwil, C.
TI  - Intra-individual comparison of (68)Ga-PSMA-11-PET/CT and multi-parametric MR for imaging of primary prostate cancer.
JO  - European journal of nuclear medicine and molecular imaging
VL  - 43
IS  - 8
SN  - 1619-7089
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DKFZ-2017-02017
SP  - 1400 - 1406
PY  - 2016
AB  - Multi-parametric magnetic resonance imaging (MP-MRI) is currently the most comprehensive work up for non-invasive primary tumor staging of prostate cancer (PCa). Prostate-specific membrane antigen (PSMA)-Positron emission tomography-computed tomography (PET/CT) is presented to be a highly promising new technique for N- and M-staging in recurrent PCa-patients. The actual investigation analyses the potential of (68)Ga-PSMA11-PET/CT to assess the extent of primary prostate cancer by intra-individual comparison to MP-MRI.In a retrospective study, ten patients with primary PCa underwent MP-MRI and PSMA-PET/CT for initial staging. All tumors were proven histopathological by biopsy. Image analysis was done in a quantitative (SUVmax) and qualitative (blinded read) fashion based on PI-RADS. The PI-RADS schema was then translated into a 3D-matrix and the euclidian distance of this coordinate system was used to quantify the extend of agreement.Both MP-MRI and PSMA-PET/CT presented a good allocation of the PCa, which was also in concordance to the tumor location validated in eight-segment resolution by biopsy. An Isocontour of 50 
KW  - Glu-NH-CO-NH-Lys-(Ahx)-((68)Ga(HBED-CC)) (NLM Chemicals)
KW  - Oligopeptides (NLM Chemicals)
KW  - Edetic Acid (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26971788
C2  - pmc:PMC4906063
DO  - DOI:10.1007/s00259-016-3346-0
UR  - https://inrepo02.dkfz.de/record/125893
ER  -