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@ARTICLE{Giesel:125893,
      author       = {F. Giesel$^*$ and F. Sterzing and H. P. Schlemmer$^*$ and
                      T. Holland-Letz$^*$ and W. Mier$^*$ and M. Rius and A.
                      Afshar-Oromieh$^*$ and K. Kopka$^*$ and J. Debus$^*$ and U.
                      Haberkorn$^*$ and C. Kratochwil},
      title        = {{I}ntra-individual comparison of
                      (68){G}a-{PSMA}-11-{PET}/{CT} and multi-parametric {MR} for
                      imaging of primary prostate cancer.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {43},
      number       = {8},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2017-02017},
      pages        = {1400 - 1406},
      year         = {2016},
      abstract     = {Multi-parametric magnetic resonance imaging (MP-MRI) is
                      currently the most comprehensive work up for non-invasive
                      primary tumor staging of prostate cancer (PCa).
                      Prostate-specific membrane antigen (PSMA)-Positron emission
                      tomography-computed tomography (PET/CT) is presented to be a
                      highly promising new technique for N- and M-staging in
                      recurrent PCa-patients. The actual investigation analyses
                      the potential of (68)Ga-PSMA11-PET/CT to assess the extent
                      of primary prostate cancer by intra-individual comparison to
                      MP-MRI.In a retrospective study, ten patients with primary
                      PCa underwent MP-MRI and PSMA-PET/CT for initial staging.
                      All tumors were proven histopathological by biopsy. Image
                      analysis was done in a quantitative (SUVmax) and qualitative
                      (blinded read) fashion based on PI-RADS. The PI-RADS schema
                      was then translated into a 3D-matrix and the euclidian
                      distance of this coordinate system was used to quantify the
                      extend of agreement.Both MP-MRI and PSMA-PET/CT presented a
                      good allocation of the PCa, which was also in concordance to
                      the tumor location validated in eight-segment resolution by
                      biopsy. An Isocontour of $50 \%$ SUVmax in PSMA-PET
                      resulted in visually concordant tumor extension in
                      comparison to MP-MRI (T2w and DWI). For $89.4 \%$ of
                      sections containing a tumor according to MP-MRI, the tumor
                      was also identified in total or near-total agreement
                      (euclidian distance ≤1) by PSMA-PET. Vice versa for
                      $96.8 \%$ of the sections identified as tumor bearing by
                      PSMA-PET the tumor was also found in total or near-total
                      agreement by MP-MRI.PSMA-PET/CT and MP-MRI correlated well
                      with regard to tumor allocation in patients with a high
                      pre-test probability for large tumors. Further research will
                      be needed to evaluate its value in challenging situation
                      such as prostatitis or after repeated negative biopsies.},
      keywords     = {Glu-NH-CO-NH-Lys-(Ahx)-((68)Ga(HBED-CC)) (NLM Chemicals) /
                      Oligopeptides (NLM Chemicals) / Edetic Acid (NLM Chemicals)},
      cin          = {C060 / E060 / E010 / E050 / E030},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E060-20160331 /
                      I:(DE-He78)E010-20160331 / I:(DE-He78)E050-20160331 /
                      I:(DE-He78)E030-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26971788},
      pmc          = {pmc:PMC4906063},
      doi          = {10.1007/s00259-016-3346-0},
      url          = {https://inrepo02.dkfz.de/record/125893},
}